枳实消痞方联合大黄神阙穴贴敷治疗阿片类药物相关性便秘临床观察  

Clinical Observation of Zhishi Xiaopi Formula Combined with Rhei Radix et Rhizoma Applied to Shenque Acupoint in the Treatment of Opioid-Induced Constipation

作　　者：毕俊芳[1] 张华[1] 申雪娜 胡秉贤 吴春燕[1] 刘新艳[1] BI Junfang;ZHANG Hua;SHEN Xuena;HU Bingxian;WU Chunyan;LIU Xinyan(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,China 050051)

机构地区：[1]河北省石家庄市中医院,河北石家庄050051

出　　处：《中国药业》2024年第6期105-108,共4页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2021262]。

摘　　要：目的探讨枳实消痞方联合大黄神阙穴贴敷治疗阿片类药物相关性便秘(OIC)的临床疗效。方法选取医院中西医结合科2021年1月至2022年1月收治的口服盐酸羟考酮缓释片治疗癌性疼痛的OIC患者70例,按随机数字表法分为观察组和对照组,各35例。观察组患者予枳实消痞方联合大黄粉神阙穴贴敷治疗,对照组患者予乳果糖口服溶液治疗,均连续用药2周。结果观察组患者的便秘治疗总有效率为85.71%,显著高于对照组的57.14%(P<0.05)。观察组患者治疗后的慢性便秘严重程度评分量表及便秘患者生活质量量表各项评分和总分均显著低于对照组(P<0.05);观察组患者的卡氏体力状况量表(KPS)评分有效率为82.86%,显著高于对照组的60.00%(P<0.05)。结论枳实消痞方联合大黄神阙穴贴敷能缓解OIC症状,改善患者的生活质量,增强其体力。Objective To investigate the clinical efficacy of Zhishi Xiaopi Formula combined with Rhei Radix et Rhizoma applied to Shenque acupoint in the treatment of opioid-induced constipation(OIC).Methods A total of 70 OIC patients treated with Oxycodone Hydrochloride Sustained-Release Tablets orally for cancer pain in the Department of Integrated Traditional Chinese and Western Medicine of the hospital from January 2021 to January 2022 were selected and divided into the observation group and the control group by the random number table method,with 35 cases in each group.The patients in the observation group were treated with Zhishi Xiaopi Formula combined with Rhei Radix et Rhizoma Powder applied to Shenque acupoint,while the patients in the control group were treated with Lactulose Oral Solution.Both groups were treated continuously for two weeks.Results The total effective rate of constipation treatment in the observation group was 85.71%,which was significantly higher than 57.14%in the control group(P<0.05).After treatment,the score of each item and total score of Chronic Constipation Severity Scale(CSS)and Patient-Assessment of Constipation Quality of Life(PAC-QOL)in the observation group were significantly lower than those in the control group(P<0.05);and the effective rate of the Karnofsky Performance Status(KPS)score in the observation group was 82.86%,which was significantly higher than 60.00%in the control group(P<0.05).Conclusion Zhishi Xiaopi Formula combined with Rhei Radix et Rhizoma applied to Shenque acupoint can relieve OIC patients′symptoms,improve quality of life,and enhance physical strength.

关 键 词：枳实消痞方 大黄 神阙穴 穴位贴敷 癌性疼痛 阿片类药物相关性便秘 临床疗效 生活质量 

分 类 号：R969.4[医药卫生—药理学]