优化使用水合氯醛镇静的方法研究  

Study of methods to optimise the use of chloral hydrate sedation

作　　者：沈艳莹 张洪锡[1] SHEN Yanying;ZHANG Hongxi(Department of Radiology,the Children’s Hospital of Zhejiang University School of Medicine,Hangzhou 310051,China)

机构地区：[1]浙江大学医学院附属儿童医院放射科,浙江杭州310051

出　　处：《实用放射学杂志》2024年第2期278-280,296,共4页Journal of Practical Radiology

摘　　要：目的分析不同年龄段儿童以及不同给药途径对水合氯醛镇静效果的影响。方法收集进行MRI检查的10671例儿童进行回顾性分析。筛选使用水合氯醛镇静的儿童,依据年龄不同分为4组:A组(0~1月)、B组(>1月~1岁)、C组(>1~2岁)、D组(>2~6岁),每组又分为口服和灌肠。记录每组的镇静成功率。数据采用SPSS 22.0软件进行分析。结果(1)A组水合氯醛镇静成功率82.5%,其中口服87.5%,灌肠85.1%;(2)B组水合氯醛镇静成功率71.8%,其中口服78.5%,灌肠71.2%;(3)C组水合氯醛镇静成功率87.7%,其中口服89.6%,灌肠82.2%;(4)D组水合氯醛镇静成功率89.6%,其中口服89.5%,灌肠90.8%。B组与A、C、D组镇静成功率存在差异,D组与A、B、C组镇静成功率存在差异,B、D组口服与灌肠镇静成功率存在差异,差异有统计学意义(P<0.05)。结论水合氯醛镇静成功率在不同年龄段存在差异。相同年龄段因给药方式不同镇静成功率也有差异。因此,有必要依据儿童年龄选择适宜的镇静策略。Objective To analyze the effects of different age groups of children and different routes of administration on the sedation effect of chloral hydrate.Methods A retrospective analysis was performed on 10671 children who underwent MRI examination.Children sedated with chloral hydrate were selected and divided into four groups according to their age:group A(0-1 month),group B(>1 month-1 year old),group C(>1-2 years old),group D(>2-6 years old),and each group was further divided into oral administration and enema administration.The success rate of sedation in each group was recorded.Data were analyzed using SPSS 22.0 software.Results(1)The sedation success rate of chloral hydrate in group A was 82.5%,including 87.5%by oral administration and 85.1%by enema administration;(2)The sedation success rate of chloral hydrate in group B was 71.8%,including 78.5%by oral administration and 71.2%by enema administration;(3)The sedation success rate of chloral hydrate in group C was 87.7%,including 89.6%by oral administration and 82.2%by enema administration;(4)The sedation success rate of chloral hydrate in group D was 89.6%,including 89.5%by oral administration and 90.8%by enema administration.There was a difference in the sedation success rate between group B and groups A,C and D,and there was a difference in the sedation success rate between group D and groups A,B,and C.There was a difference in the sedation success rate of oral administration versus enema administration between groups B and D.The differences were statistically significant(P<0.05).Conclusion The sedation success rate of chloral hydrate is different in different age groups,the sedation success rate in the same age group is also different due to different administration methods.Therefore,it is necessary to choose the appropriate sedation strategy according to the age of children.

关 键 词：水合氯醛 镇静 磁共振成像 儿童 

分 类 号：R452[医药卫生—治疗学] R445.2[医药卫生—临床医学]