肝豆状核变性合并月经不调中医证候调查及其相关因素分析  

Investigation on TCM Syndrome of Hepatolenticular Degeneration Combined with Irregular Menstruation and Analysis of Related Factors

作　　者：王梦丽 韩辉 吴丽敏[2] 方小茹[1,2] 陈秋莹 WANG Mengli;HAN Hui;WU Limin;FANG Xiaoru;CHEN Qiuying(Anhui University of Traditional Chinese Medicine,Hefei 230038,Anhui,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,(Anhui Provincial Hospital)Hefei 230031,Anhui,China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230038 [2]中国科学技术大学附属第一医院(安徽省立医院),安徽合肥230001

出　　处：《辽宁中医杂志》2024年第2期1-5,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81971446,81373671);安徽省科技厅临床专项转化项目(202204295107020044);安徽省教育厅重点项目(2022AH050523);安徽省红十字会中医药传承创新发展研究项目(2022ZYYD24)。

摘　　要：目的通过研究女性肝豆状核变性合并月经不调中医证候特征,为肝豆状核变性合并月经不调中医诊治提供参考。方法按照肝豆状核变性和月经不调的临床诊断标准,采用流行病学调查问卷对294例女性肝豆状核变性患者的月经情况进行调查,根据有无合并月经不调将294例肝豆状核变性患者分为研究组(合并月经不调)213例和对照组(无合并月经不调)81例,分析并比较两组中医证候分布特征,并通过对研究组进一步调查,分析合并月经不调患者中医证候分布与年龄、临床分型的关联情况。结果213例合并月经不调的肝豆状核变性患者月经不调的类型分布相对广泛,其中以月经后期、月经过少、月经过多最为常见,月经先期、月经先后无定期、痛经相对常见,而合并崩漏者较为少见。研究组频率最高的十个中医症状依次为腹部胀痛、腰膝酸软、五心烦热、言语謇涩、张口流涎、食欲不振、头目昏眩、四肢震颤、喜温喜按、口中臭秽;对照组频率最高的十个中医症状依次为:言语謇涩、头目昏眩、腹部胀痛、四肢震颤、口中臭秽、张口流涎、食欲不振、腰膝酸软、五心烦热、喜温喜按。研究组中医证型以肝肾阴虚证、痰瘀互结证、脾肾阳虚证为主。对照组以痰瘀互结证、湿热内蕴证为主。与对照组比较,研究组肝肾阴虚证、脾肾阳虚证分布率显著高于对照组(P<0.05);对照组痰瘀互结证、湿热内蕴证分布率显著高于研究组(P<0.05);痰湿阻络证、气虚血瘀证、痰火扰心证分布率差异无统计学意义(P>0.05)。研究组的年龄分布主要分布在26~35岁,其临床分型主要以混合型为主。结论肝豆状核变性患者月经不调的分类以月经后期、月经过少、月经过多为主,肝肾阴虚证、痰瘀互结证、脾肾阳虚证为女性肝豆状核变性患者合并月经不调常见中医证候,各证型分布与患者年龄、临床�Objective To study the TCM syndrome characteristics of female hepatolenticular degeneration combined with irregular menstruation and provide reference for the diagnosis and treatment of hepatolenticular degeneration combined with irregular menstruation by traditional Chinese medicine.Methods According to the clinical diagnostic criteria of hepatolenticular degeneration and irregular menstruation,an epidemiological questionnaire was used to investigate the menstrual status of 294 female patients with hepatolenticular degeneration.The patients with lenticular degeneration were divided into 213 cases in the study group(with irregular menstruation)and 81 cases in the control group(without irregular menstruation).The distribution characteristics of TCM syndromes in the two groups were analyzed and compared.The correlation of TCM syndrome distribution with age and clinical types in patients with irregular menstruation was studied.Results The types of irregular menstruation in 213 patients with hepatolenticular degeneration combined with irregular menstruation were relatively widely distributed.Among them,late menstruation,oligomenorrhea and menorrhagia were the most common,and premenstrual,irregular menstruation and dysmenorrhea were relatively common.The combined uterine bleeding was relatively rare.The ten most frequent TCM symptoms in the study group were abdominal distention and pain,soreness and weakness of waist and knees,five heart upsets and heat,slurred speech,drooling mouth,loss of appetite,dizziness,tremor of limbs,liking for warmth and pressing,foul smell in the mouth.The ten most frequent TCM symptoms in the control group were slurred speech,dizziness,abdominal pain,tremors in the limbs,foul smell in the mouth,salivation,loss of appetite,soreness and weakness of the waist and knees,five upsets and heat,and liking for warmth and pressing.The TCM syndrome types in the study group were mainly the syndrome of liver-kidney Yin deficiency,phlegm and blood stasis syndrome,and spleen-kidney Yang deficiency syndrom

关 键 词：肝豆状核变性 月经不调 中医证候 

分 类 号：R271.111[医药卫生—中医妇科学]