补肾活血法与葛根黑苏汤对薄型子宫内膜不孕症治疗作用的影响  

Effect of Kidney-Invigorating and Blood-Activating Method and Gegen Heisu Decoction(葛根黑苏汤)on TCM Syndrome Score and Inflammation in Patients with Thin Endometrial Infertility

作　　者：赵欣 刘淑君[1] 吴聪哲[2] 李丹丹 ZHAO Xin;LIU Shujun;WU Congzhe;LI Dandan(Tangshan Hospital of traditional Chinese medicine,Tangshan 063000,Hebei,China;Tangshan Union Medical College Hospital,Tangshan 063000,Hebei,China;Tangshan Central Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市中医医院,河北唐山063000 [2]唐山市协和医院,河北唐山063000 [3]唐山市中心医院,河北唐山063000

出　　处：《辽宁中医杂志》2024年第2期126-130,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2021395)。

摘　　要：目的探究补肾活血法与葛根黑苏汤对薄型子宫内膜不孕症患者中医证候积分及炎症的影响。方法选取2020年3月—2022年3月在该院妇科就诊的80例薄型子宫内膜不孕症患者,按随机数字表法将分为对照组和观察组,各40例。对照组采用葛根黑苏汤治疗,观察组采用葛根黑苏汤联合补肾活血法治疗。对比两组患者中医证候积分、子宫内膜厚度、血清血管内皮生长因子(vascubr endothelial growth factor,VEGF)、子宫血流动力学、血清雌二醇及孕酮、子宫内膜类型、血清炎症因子水平。结果治疗后,两组中医证候积分均下降,且对照组明显低于观察组(P<0.05)。治疗前两组子宫内膜厚度以及血清VEGF水平比较,差异无统计学意义(P>0.05),治疗后,两组子宫内膜厚度以及血清VEGF水平均升高(P<0.05),且观察组低于对照组。治疗前两组子宫血流动力学指标水平比较,差异无统计学意义(P>0.05);治疗后,两组搏动指数、阻力指数均降低,收缩期血流速度加快,差异无统计学意义(P<0.05);观察组收缩期血流速度快于对照组,搏动指数、阻力指数低于对照组。治疗前两组血清雌二醇与孕酮水平比较,差异无统计学意义(P>0.05);两组患者血浆中的雌二醇和黄体素含量均升高,而对照组则显著增高(P<0.05)。治疗前两组子宫内膜A+B型与C型数量比较,差异无统计学意义(P>0.05);治疗后对照组A+B型数量高于对照组,C型数量低于对照组(P<0.05)。治疗前两组血清因子水平比较,差异无统计学意义(P>0.05)。治疗后两组血清因子水平均下降,且对照组低于观察组(P<0.05)。结论采用补肾活血法联合葛根黑苏汤治疗薄型子宫内膜不孕症能减轻患者的中医证候,改善患者子宫内膜形态、厚度,调节患者血清VEGF水平、血流动力学、血清雌二醇及孕酮水平,降低血清炎症因子,值得在临床上进一步推广使用。Objective To explore the effects of kidney-invigorating and blood-activating method and Gegen Heisu Decoction(葛根黑苏汤)on TCM syndrome scores and inflammation in patients with thin endometrial infertility.Methods A total of 80 patients with thin endometrial infertility who were treated in the gynecology department of the hospital from March 2020 to March 2022 were selected and divided into a control group and an observation group according to the random number table,40 cases in each group.The control group was treated with Gegen Heisu Decoction,and the observation group was treated with Gegen Heisu Decoction combined with kidney-invigorating and blood-activating method.The TCM syndrome scores,endometrial thickness,serum vascular endothelial growth factor(VEGF),uterine hemodynamics,serum estradiol and progesterone,endometrial types and serum inflammatory factor levels were compared between the two groups.Results After treatment,TCM syndrome scores in both groups decreased,and the score of the control group was significantly lower than that of the observation group(P<0.05).Before treatment,the endometrial thickness and serum VEGF level of the two groups were compared(P>0.05).After treatment,the endometrial thickness and serum VEGF level of the two groups were increased(P<0.05),and those of the observation group were lower than those of the control group.The comparison of uterine hemodynamic index levels between the two groups before treatment had no significance(P>0.05).After treatment,the pulsatility index and resistance index of the two groups were decreased,and the systolic blood flow velocity was accelerated(P<0.05).The systolic blood flow velocity of the observation group was faster than that of the control group.The pulsatility index and resistance index were lower than those of the control group.Before treatment,the levels of serum estradiol and progesterone in the two groups were not(P>0.05).The levels of estradiol and progesterone in the plasma of the two groups were increased,while those of the con

关 键 词：薄型子宫内膜不孕症 补肾活血法 葛根黑苏汤 中医证候积分 炎症 

分 类 号：R271.14[医药卫生—中医妇科学]