体外冲击波碎石联合体外物理振动排石治疗输尿管结石患者的有效性及安全性探讨  

Exploration of the Effectiveness and Safety of Extracorporeal Shock Wave Lithotripsy Combined with Extracorporeal Physical Vibration Lithotripsy in the Treatment of Patients with Ureteral Stones

作　　者：林小荣[1] Lin Xiaorong(Department of Urology,Quanzhou Guangqian Hospital,Quanzhou,Fujian,362321,China)

机构地区：[1]福建省泉州市光前医院泌尿外科,福建泉州362321

出　　处：《黑龙江医学》2024年第6期672-674,共3页Heilongjiang Medical Journal

摘　　要：目的:观察体外冲击波碎石联合体外物理振动排石治疗输尿管结石患者的有效性及安全性。方法:选取福建省泉州市光前医院2020年1月—2022年1月收治的输尿管结石患者88例,使用随机数表法将其分为常规组(44例)及研究组(44例),常规组患者给予自然排石治疗,研究组采用体外物理振动排石治疗。观察两组患者治疗效果、排石效果、不良反应发生率及治疗前后肾功能、β_(2)-微球蛋白(β_(2)-MG)、血清胱抑素C (Cys-C)、尿微量白蛋白(mAlb)水平情况。结果:研究组患者总有效率高于常规组,结石平均排出时间显著低于常规组患者,差异有统计学意义(χ^(2)=4.456、3.614,P<0.05);研究组患者当天排石率及2周结石排净率高于常规组患者,差异有统计学意义(χ^(2)=10.313、9.140,P<0.05);治疗后,研究组患者血肌酐(Scr)、尿素氨(BUN)显著低于常规组患者,差异有统计学意义(t=9.218、10.561,P<0.05);治疗后,研究组患者β_(2)-MG、Cys-C、mAlb水平显著低于常规组患者,差异有统计学意义(t=4.663、5.685、7.432,P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(χ^(2)=0.301,P>0.05)。结论:体外冲击波碎石联合体外物理振动排石治疗输尿管结石能有效提高患者治疗疗效,促进患者结石排出,提高患者肾功能且不增加不良反应发生率,具有较好疗效及安全性。Objective:To observe the effectiveness and safety of extracorporeal shock wave lithotripsy combined with extracorporeal physical vibration lithotripsy in the treatment of patients with ureteral stones.Methods:88 patients with ureteral stones admitted to the hospital from January 2020 to January 2022 were selected and divided into the conventional group(44patients) and the study group(44 patients) with the random number table method.Patients in the conventional group were given natural stone removal,and the research group was treated with extracorporeal physical vibration stone removal.The treatment effect,lithotripsy effect,incidence of adverse reactions and expression of renal function,β2-microglobulin(β2-MG),serum cystatin C(Cys-C),and urinary microalbumin(mAlb) levels before and after treatment were observed in the two groups.Results:The total effective rate of patients in the study group was higher than that of the conventional group,and the average time of stone expulsion was significantly lower than that of patients in the conventional group,with statistically significant differences(χ^(2)=4.456,3.614;P<0.05).The rate of stone expulsion on the same day and the rate of stone expulsion in 2 weeks were higher in the study group than in the conventional group,and the difference was statistically significant(χ^(2)=10.313,9.140;P<0.05).After treatment,Scr and BUN of the study group were significantly lower than those of patients in the conventional group,and the difference was statistically significant(t=9.218,10.561;P<0.05).After treatment,the β2-MG,Cys-C,and mAlb levels of patients in the study group were significantly lower than those of patients in the conventional group,and the difference was statistically significant(t=4.663,5.685,7.432;P<0.05).The difference in the total incidence of adverse reactions between the two groups was not statistically significant(χ^(2)=0.301,P>0.05).Conclusion:Extracorporeal shock wave lithotripsy combined with extracorporeal physical vibration lithotripsy for the treatmen

关 键 词：体外冲击波碎石 体外物理振动排石 疗效 安全性 肾功能 

分 类 号：R693.4[医药卫生—泌尿科学]