中医“序贯三法”用药对早期2型糖尿病患者胰岛素抵抗及血清成纤维细胞因子21水平的影响  

The effect of"Sequential Three Methods"of Traditional Chinese Medicine on insulin resistance and serum fibroblast growth factor-21 levels in patients with early type 2 diabetes

作　　者：傅青斌 吴志华 彭志明 FU Qingbin;WU Zhihua;PENG Zhiming(Third Department of Internal medicine,Guixi Traditional Chinese Medicine Hospital,Yingtan,Jiangxi,335400,China)

机构地区：[1]贵溪市中医院内三科,江西鹰潭335400

出　　处：《当代医学》2023年第26期75-79,共5页Contemporary Medicine

摘　　要：目的探讨中医“序贯三法”用药对早期2型糖尿病(T2DM)患者胰岛素抵抗(IR)及血清成纤维细胞因子21(FGF-21)水平的影响。方法选取2020年1月至2021年1月贵溪市中医院收治的60例T2DM患者作为研究对象,随机分为参照组(n=29)与实验组(n=31)。比较两组临床疗效,治疗前后IR指标[胰岛素抵抗指数(HOMA-IRI)、胰岛β细胞功能指数(HOMA-β)]、FGF-21、生长素释放肽(Ghrelin)的水平。结果实验组治疗总有效率为93.55%,高于参照组的68.97%,差异有统计学意义(P<0.05)。治疗后,两组HOMA-IRI均低于治疗前,HOMA-β均高于治疗前,且实验组HOMA-IRI低于参照组,HOMA-β高于参照组,差异有统计学意义(P<0.05)。治疗后,两组FGF-21水平均低于治疗前,Ghrelin水平均高于治疗前,且实验组FGF-21水平低于参照组,Ghrelin水平高于参照组,差异有统计学意义(P<0.05)。结论采用中医“序贯三法”用药治疗早期T2DM疗效确切,可快速降低患者血糖水平,用药效果良好,明显改善患者IR状态,促进血糖恢复正常。Objective To investigate the effects of three sequential methods of Traditional Chinese Medicine on insulin resistance(IR)and serum fibroblast growth factor-21(FGF-21)levels in patients with early type 2 diabetes mellitus(T2DM).Methods A total of 60 T2DM patients admitted to Guixi Traditional Chinese Medicine Hospital from January 2020 to January 2021 were selected as the study subjects,and they were randomly divided into the reference group(n=29)and the experimental group(n=31),the clinical efficacy,and the changes of IR indexes(homeostatic model assessment of insulin resistance index[HOMA-IRI],homeostasis model assessment ofβcell[HOMA-β]),FGF-21 and growth hormone-releasing peptide(Ghrelin)levels before and after treatment were compared between the two groups.Results The total effective rate in the experimental group was 93.55%,which was higher than 68.97%in the reference group,and the difference was statistically significant(P<0.05).After treatment,HOMA-IRI of the two groups was lower than before treatment,the HOMA-βwas higher than before treatment,and HOMA-IRI in the experimental group was lower than that in reference group,and HOMA-βwas higher than that in reference group,the differences were statistically significant(P<0.05).After treatment,the levels of FGF-21 of the two groups were lower than before treatment,the levels of Ghrelin were higher than before treatment,and the level of FGF-21 in the experimental group was lower than that in the reference group,and the level of Ghrelin was higher than that in the reference group,the differences were statistically significant(P<0.05).Conclusion The use of"Sequential Three Methods"of Traditional Chinese Medicine in the treatment of early T2DM is effective,can quickly reduce the blood sugar level of patients,the drug effect is good,obviously improve the IR status of patients,and promote the blood sugar to return to normal.

关 键 词：早期 中药 2型糖尿病 序贯三法 成纤维细胞因子 

分 类 号：R587.1[医药卫生—内分泌]