血清Gal-3、TWEAK对精神分裂症的诊断价值及与精神症状严重程度的关系  

Diagnostic value of serum Gal-3 and TWEAK in schizophrenia and their relationship with severity of mental symptoms

作　　者：权涛涛 柏林[1] 于洋 张丹 QUAN Taotao;BAI Lin;YU Yang;ZHANG Dan(Department of Psychiatry,Changping District Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 102208,China)

机构地区：[1]北京市昌平区中西医结合医院精神科,北京102208

出　　处：《检验医学与临床》2024年第6期800-804,共5页Laboratory Medicine and Clinic

基　　金：首都卫生发展科研专项项目(首发2020-2-7016)。

摘　　要：目的研究血清半乳糖凝集素3(Gal-3)、肿瘤坏死因子样弱凋亡诱导因子(TWEAK)对精神分裂症的诊断价值及与精神症状严重程度的关系。方法选取2019年3月至2021年3月在该院诊治的96例精神分裂症患者作为病例组,以同期60例健康体检者为对照组,进行回顾性分析。采用酶联免疫吸附试验检测血清Gal-3、TWEAK水平。采用Pearson相关分析血清Gal-3、TWEAK水平与临床指标的相关性;采用多因素Logistic回归分析影响精神分裂症发生的因素;采用受试者工作特征(ROC)曲线分析血清Gal-3、TWEAK单项及联合检测对精神分裂症的诊断价值。结果观察组PANSS评分总分、阳性症状评分、阴性症状评分、一般精神病理学症状评分及血清Gal-3、TWEAK水平均高于对照组,差异均有统计学意义(P<0.001)。血清Gal-3、TWEAK水平与PANSS评分总分、阳性症状评分、阴性症状评分、一般精神病理学症状评分呈正相关(P<0.001)。PANSS评分总分、阳性症状评分、一般精神病理学症状评分升高及血清Gal-3、TWEAK水平升高均是精神分裂症发生的独立危险因素(P<0.001)。血清Gal-3、TWEAK联合检测诊断精神分裂症的曲线下面积为0.870(95%CI:0.831~0.919),明显高于血清Gal-3、TWEAK单项检测诊断精神分裂症的AUC[0.812(95%CI:0.769~0.847)、0.820(95%CI:0.771~0.852)],差异均有统计学意义(Z=4.345,P<0.001;Z=4.010,P=0.002)。结论精神分裂症患者血清Gal-3、TWEAK水平升高,二者与精神症状严重程度有关,血清Gal-3、TWEAK联合检测对精神分裂症具有较高的诊断价值。Objective To study the diagnostic value of serum galactose agglutinin 3(Gal-3) and tumor necrosis factor like weak apoptosis inducing factor(TWEAK) in schizophrenia and their relationship with the severity of psychiatric symptoms.Methods A retrospective analysis was conducted on 96 patients with schizophrenia diagnosed and treated in this hospital from March 2019 to March 2021 as the case group,and 60 healthy individuals undergoing physical examinations during the same period as the control group.The enzyme linked immunosorbent assay was used to detect serum Gal-3 and TWEAK levels.The Pearson correlation was adopted to analyze the correlation between serum Gal-3 and TWEAK levels with clinical indicators;the multiple Logistic regression was used to analyze the factors influencing the occurrence of schizophrenia;the diagnostic value of serum Gal-3,TWEAK single and combined detection for schizophrenia was analyzed by the receiver operating characteristic(ROC) curve.Results The PANSS total score,positive symptom score,negative symptom score,general psychopathological symptom score and serum Gal-3 and TWEAK levels in the observation group were all higher than those in the control group,and the differences were statistically significant(P<0.001).The serum Gal-3 and TWEAK levels were positively correlated with the total PANSS score,positive symptom score,negative symptom score and general psychopathological symptom score(P<0.001).The increase of total PANSS score,positive symptom score and general psychopathological symptom score and the increase of serum Gal-3 and TWEAK levels all were the independent risk factors for the occurrence of schizophrenia(P<0.001).The area under the curve of serum Gal-3 and TWEAK combined detection for diagnosing schizophrenia was 0.870(95%CI:0.831-0.919),which was significantly higher than AUC of serum Gal-3 and TWEAK single detection for diagnosing schizophrenia [0.812(95%CI:0.769-0.847),0.820(95%CI:0.771-0.852)],and the differences were statistically significant(Z=4.345,P<0.001;Z=4.010,P=

关 键 词：精神分裂症 半乳糖凝集素3 肿瘤坏死因子样弱凋亡诱导因子 诊断 精神症状 

分 类 号：R446.11[医药卫生—诊断学] R749.3[医药卫生—临床医学]