中药多途径治疗对输卵管阻塞性不孕症患者术后输卵管复通率、血清CTGF水平及子宫动脉血流的影响  

Effect of multipath traditional Chinese medicine treatment on the fallopian tube recanalization rate,serum CTGF level,and uterine artery blood flow in patients with tubal obstruction infertility after surgery

作　　者：白珍珍 孟慧玲 于迎新 BAI Zhen-zhen;MENG Hui-ling;YU Ying-xin(Department of Gynecology,Cangzhou Maternal and Child Health Hospital,Cangzhou Hebei 061001,China)

机构地区：[1]沧州市妇幼保健院妇科,河北沧州061001

出　　处：《临床和实验医学杂志》2024年第3期281-285,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省中医药管理局中医药类科研计划课题(编号:2021357)。

摘　　要：目的 探究中药多途径治疗对输卵管阻塞性不孕症患者术后输卵管复通率、血清结缔组织生长因子(CTGF)水平及子宫动脉血流的影响。方法 采用前瞻性研究,选取2020年12月至2022年12月沧州市妇幼保健院收治的104例输卵管阻塞性不孕症患者作为研究对象,按照随机数字表法将其分为观察组和对照组,每组各52例。对照组患者采用宫腹腔镜进行手术治疗,观察组在对照组手术治疗的基础上给予中药多途径治疗(包括中药汤剂口服治疗、中药保留灌肠治疗和中药离子导入治疗3种方式)。比较两组患者的中医证候积分、输卵管复通率、实验室指标[CTGF和白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]和子宫内膜容受性指标[宫内膜动脉阻力指数(RI)、搏动指数(PI)、内膜厚度、内膜类型]情况。结果 治疗后,两组患者的下腹胀痛、白带、输卵管畅通度和舌脉等中医证候积分均较治疗前降低,且观察组患者的各项中医证候积分分别为(1.46±0.34)、(0.88±0.43)、(1.71±0.44)、(1.46±0.43)分,均显著低于对照组[(3.17±0.62)、(1.77±0.61)、(2.56±0.78、(2.29±0.66)分],差异均有统计学意义(P<0.05)。观察组患者的输卵管复通率为96.15%,显著高于对照组(80.77%),差异有统计学意义(P<0.05)。与治疗前相比,治疗后,两组血清CTGF、IL-6和TNF-α水平均显著降低,且观察组患者的血清CTGF、IL-6和TNF-α水平分别为(2.24±0.52)μg/L、(0.91±0.22)pg/mL、(41.33±6.27)pg/mL,均显著低于对照组[(2.81±0.88)μg/L、(1.47±0.46)pg/mL、(60.14±9.84)pg/mL],差异均有统计学意义(P<0.05)。观察组患者的RI、PI、子宫内膜厚度和子宫内膜A型,子宫内膜容受性指标差值分别为0.49±0.13、0.51±0.11、(1.84±0.20)mm、(24.15±2.96)%,均高于对照组[0.20±0.09、0.25±0.07、(1.27±0.15)mm、(14.56±2.04)%],差异均有统计学意义(P<0.05)。结论 中药多途径治疗能够有效改善输卵管阻塞性不孕症患�Objective To explore the effect of multipath traditional Chinese medicine treatment on the fallopian tube recanalization rate,serum connective tissue growth factor(CTGF) level,and uterine artery blood flow in patients with tubal obstructive infertility after surgery.Methods Using a prospective study,104 patients with tubal obstructive infertility admitted to Cangzhou Maternal and Child Health Hospital from December 2020 to December 2022 were selected as the study subjects.They were divided into an observation group and a control group using the random number table method,with 52 cases in each group.The control group was treated with laparoscopic surgery,while the observation group was treated with multipath traditional Chinese medicine treatment(including three methods:oral treatment with traditional Chinese medicine decoction,retention enema treatment with traditional Chinese medicine,and ion introduction treatment with traditional Chinese medicine) on the basis of surgical treatment in the control group.The traditional chinese medicine syndrome scores,fallopian tube recanalization rate,laboratory indicators[CTGF,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and endometrial receptivity[endometrial artery resistance index(RI),pulsatility index(PI),endometrial thickness,endometrial type] of the two groups were compared.Results After treatment,the traditional chinese medicine syndrome scores of lower abdominal distension,vaginal discharge,fallopian tube patency,and tongue and pulse in two groups of patients were lower than those before treatment,the traditional chinese medicine syndrome scores of the observation group were(1.46±0.34),(0.88±0.43),(1.71±0.44),and(1.46±0.43) points,respectively,which were significantly lower than those of the control group [(3.17±0.62),(1.77±0.61),(2.56±0.78),and(2.29±0.66) points],and the differences were statistically significant(P<0.05).The rate of fallopian tube recanalization in the observation group was 96.15%,which was significantly higher than that in the contr

关 键 词：中药多途径用药治疗 输卵管阻塞性不孕症 输卵管复通率 结缔组织生长因子 子宫动脉血流 

分 类 号：R711.6[医药卫生—妇产科学]