麝香保心丸对微血管心绞痛血管内皮功能的影响  

Effect of Shexiangbaoxin Pill on vascular endothelial function in patients with primary microvascular angina

作　　者：黄琪[1] 隋向前[1] 蒋凤春[1] 何武剑 裴德安[1] 王士生[1] 胡永宾[2] HUANG Qi;SUI Xiangqian;JIANG Fengchun;HE Wujian;PEI Dean;WANG Shisheng;HU Yongbin(Department of Cardiology,Hangzhou Red Cross Hospital,Hangzhou 310003,Zhejiang,China;Department of Endocrinology,Hangzhou Red Cross Hospital,Hangzhou 310003,Zhejiang,China)

机构地区：[1]杭州市红十字会医院心内科,浙江杭州310003 [2]杭州市红十字会医院内分泌科,浙江杭州3100031

出　　处：《中国现代医生》2024年第8期74-78,共5页China Modern Doctor

基　　金：中国中西医结合学会——和黄药业科研基金(2019006);浙江省中医药科技计划项目(2020ZA083);浙江省医药卫生科技计划项目(2019KY510,2020KY220)。

摘　　要：目的测定原发性微血管心绞痛(primarymicrovascular angina,PMVA)患者血浆血管性假血友病因子(von Willebrand factor,v WF)水平评价血管内皮功能,观察给予麝香保心丸治疗前后v WF水平的改变。方法明确诊断PMVA的患者69例,采用随机数字表法分为常规治疗组33例和麝香保心丸组36例,比较两组患者治疗前后vWF水平。结果常规治疗组治疗前vWF(50.93±32.98)μg/L治疗后v WF(49.65±35.12)μg/L,麝香保心丸组治疗前v WF(27.45±25.02)μg/L治疗后v WF(17.37±15.68)μg/L。治疗后vWF下降值麝香保心丸组(10.08±16.47)μg/L较常规治疗组(1.28±12.37)μg/L更明显,P<0.05。结论麝香保心丸具有血管内皮保护功能,PMVA患者能从治疗中获益。Objective The plasma von Willebrand factor(vWF)level in patients with primary microvascular angina(PMVA)were measured to evaluate the vascular endothelial function of the patients.The change of vWF level in patients after the treatment with Shexiangbaoxin Pill were observeg.Methods Totally 69 patients who were definitely diagnosed as PMVA,They were randomly divided into conventional treatment group(33cases)and ShexiangBaoxin Pill group(36cases).The plasma vWF levels of the two groups were measured before and after treatment.Results The level of vWF before treatment in conventional treatment group was(50.93±32.98)μg/L.The level of vWF before treatment in ShexiangBaoxin Pill group was(27.45±25.02)μg/L.The level of vWF in conventional treatment group after treatment was(49.65±35.12)μg/L.The level of vWF after treatment in ShexiangBaoxin Pill group was(17.37±15.68)μg/L.The difference of vWF decrease in Baoxin Pill group after treatment(10.08±16.47)μg/L,was lower than that in conventional treatment group(1.28±12.37)μg/L,the difference is significant(P<0.05).Conclusion Shexiang Baoxin Pill has the function of protecting vascular endothelium,and PMVA patients can benefit from treatment.

关 键 词：麝香保心丸 原发性微血管心绞痛 血管内皮功能 血管性假血友病因子 

分 类 号：R541[医药卫生—心血管疾病]