2013—2022年河南省南阳市含脑膜炎球菌成分疫苗疑似预防接种异常反应监测  

Surveillance analysis of adverse event following immunization for meningococcal vaccines in Nanyang city,Henan province,2013-2022

作　　者：张绍丽[1] 王荣记 任礼飞 师建起 孙航 刘旭 ZHANG Shaoli;WANG Rongji;REN Lifei;SHI Jianqi;SUN Hang;LIU Xu(Nanyang Center for Disease Control and Prevention,Nanyang 473000,China;Fangcheng County Center for Disease Control and Prevention)

机构地区：[1]南阳市疾病预防控制中心,河南南阳473000 [2]方城县疾病预防控制中心

出　　处：《现代疾病预防控制》2024年第2期99-102,112,共5页MODERN DISEASE CONTROL AND PREVENTION

摘　　要：目的分析南阳市A群脑膜炎球菌多糖疫苗(MPV-A)、A群C群脑膜炎球菌多糖疫苗(MPV-AC)、A群C群脑膜炎球菌多糖结合疫苗(MPCV-AC)、ACYW135群脑膜炎球菌多糖疫苗(MPV-ACYW135)和A群C群脑膜炎球菌结合b型流感嗜血杆菌结合联合疫苗(MPCV-AC-Hib)疑似预防接种异常反应(AEFI)发生特征,初步评价疫苗安全性。方法通过中国AEFI监测管理系统和河南省免疫规划信息管理系统收集2013—2022年南阳市MPV-A、MPV-AC、MPCVAC、MPV-ACYW135和MPCV-AC-Hib 5种含MPV疫苗接种剂次数和AEFI个案数,采用描述流行病学进行分析。结果2013—2022年南阳市共报告AEFI 1979例,年均报告发生率40.22/10万剂。5种疫苗不良反应报告发生率在20.80/10万剂~60.83/10万剂,差异有统计学意义(χ^(2)=293.203,P<0.05)。一般反应1966例,发生率为39.96/10万剂;异常反应10例,发生率为0.20/10万剂。一般反应的主要临床症状为发热(1600例,81.38%),发生率为32.52/10万剂;异常反应中过敏性皮疹6例(60.00%),发生率为0.12/10万剂。1977例(99.90%)AEFI病例转归为痊愈。结论2013—2022年南阳市含MPV疫苗预防接种后不良反应报告发生率低,多为一般反应,预后好,疫苗安全性良好。Objective To analysis characteristics of adverse event following immunization(AEFI)for group A meningococcal polysaccharide vaccine in(MPV-A),group A and C meningococcal polysaccharide vaccine(MPV-AC),group A and C meningococcal polysaccharide conjugate vaccine(MPCV-AC),group ACYW135 meningococcal polysaccharide vaccine(MPVACYW135),and group A and C meningococcal conjugate Haemophilus influenza type b conjugate combination vaccine(MPCVAC-Hib)in Nanyang city,and preliminarily evaluate vaccine safety.Methods AEFI cases and vaccination doses of the five meningococcal vaccines(MPV-A,MPV-AC,MPCV-AC,MPV-ACYW135,and MPCV-AC-Hib)administered and reported from Nanyang between 2013-2022 were collected through China AEFI Surveillance and Management System and Henan Information Management Systems for Immunization.Analysis was performed using the description epidemiology.Results In total,1979 AEFI cases were reported from Nanyang between 2013-2022,and the average annual reported incidence was 40.22/105doses.The reported incidence of AEFI for the 5 vaccines was between 20.80/105-60.83/105doses with a significant difference(χ2=293.203,P<0.05).There were 1966 general reactions reported with the incidence rate of 39.96/105.Abnormal reactions occurred in 10cases with the incidence of 0.20/105doses.The main clinical symptoms of the general reactions were fever(1600 cases,81.38%),with the incidence of 32.52/105doses;abnormal reactions were mainly diagnosed as allergic rash(6 cases,60.00%)with the incidence of 0.12/105doses.Of the AEFI cases,1977(99.90%)were recovered.Conclusions From 2013-2022,the reported incidence of AEFI for meningococcal vaccines used in Nanyang city was low;most of them were general reactions,having good prognosis;and the vaccines had good safety.

关 键 词：脑膜炎球菌疫苗 疑似预防接种异常反应 安全性 

分 类 号：R186[医药卫生—流行病学]