迁移体生物发生的时空图谱  

Spatio-Temporal Map of Migrasome Biogenesis

作　　者：王维丝 黄雨薇 WANG Weisi;HUANG Yuwei(School of Basic Medical Sciences,Xi’an Jiaotong University,Xi’an 710049,China)

机构地区：[1]西安交通大学基础医学院,西安710049

出　　处：《中国细胞生物学学报》2024年第1期11-20,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32370734、32070691)资助的课题。

摘　　要：迁移体是2015年被发现的新型细胞器,是在细胞迁移后端收缩丝上生长起来的囊泡状结构。迁移体参与细胞与细胞间、细胞与微环境间的信息交流和物质交换,在胚胎发育、血管新生、线粒体稳态维持、病毒传播等生理病理过程中发挥着重要作用。近年来,研究者们针对迁移体的形成过程展开了系统探索,并逐步揭示了迁移体的生物发生及动态调控机制,为迁移体的功能探索奠定了理论基础,也为以迁移体为抓手的临床应用提供了切入点。该文将对迁移体发生及调控机制的相关研究进行系统梳理,绘制迁移体生物发生过程的时空图谱,以期为迁移体领域的研究提供指导与参考。Migrasome,a novel organelle discovered in 2015,is a vesicular structure that grows on the retraction fibers at the rear of migrating cells.It is involved in the communication and material exchange between cells and their micro-environment,and plays a significant role in physiological and pathological processes such as embryonic development,angiogenesis,maintenance of mitochondrial homeostasis,and viral transmission.In recent years,researchers have systematically explored the formation process of migrasomes,gradually revealing their biogenesis and dynamic regulatory mechanisms.This has laid the foundation for a deeper understanding of migrasomes and provided a theoretical basis for exploring their functions and potential applications.This article aims to provide a systematic review and summary of relevant studies on the occurrence and regulation mechanisms of migrasomes,and to depict a spatio-temporal map of their formation and regulation,serving as a reference for future research in this field.

关 键 词：迁移体 整合素 tetraspanin富集的微结构域 鞘磷脂 磷脂酰肌醇4 5-二磷酸盐 

分 类 号：Q244[生物学—细胞生物学]