病原体与宿主核外细胞器  

Pathogens and Extranuclear Organelles

作　　者：袁桢 张福海 丁彬彬 YUAN Zhen;ZHANG Fuhai;DING Binbin(School of Basic Medicine,Huazhong University of Science and Technology,Wuhan 430030,China;Guangzhou National Laboratory,Guangzhou 510320,China;State Key Laboratory of Respiratory Disease,Guangzhou 510182,China)

机构地区：[1]华中科技大学基础医学院,武汉430030 [2]广州国家实验室,广州510320 [3]呼吸疾病全国重点实验室,广州510182

出　　处：《中国细胞生物学学报》2024年第1期179-192,共14页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32370809、92054107、U22A20337)资助的课题。

摘　　要：多种类型的病原体如细菌、病毒和寄生虫等已经进化出复杂的策略,通过操控并改造宿主细胞中的各个细胞器,重塑细胞内部环境,为它们持续生存和繁殖提供便利条件。该文总结了病原体靶向调控自噬体、溶酶体、内质网、线粒体、高尔基体、脂滴和过氧化物酶体的机制和生理功能,为更深入地了解病原体的复制特点和致病机理及治疗提供参考。Various types of pathogens,such as bacteria,viruses and parasites,have acquired complex strategies in manipulating and modifying various organelles to provide optimal conditions for their survival and reproduction.This review summarizes the virulence mecahnisms and physiological functions of pathogens targeting autophagosomes,lysosome,endoplasmic reticulum,mitochondria,Golgi apparatus,lipid droplets and peroxisome.This review provides the insights for further understanding the pathogenesis and treatment of pathogens.

关 键 词：病原体 自噬体 溶酶体 内质网 线粒体 高尔基体 脂滴 过氧化物酶体 

分 类 号：Q244[生物学—细胞生物学]