鹅膏环肽类毒素检测技术的研究进展  

Research progress on detection techniques of Amanita cyclic peptide toxins

作　　者：姜奕甫 郎乐 张成龙 赵凌艺 杨瑞琴 JIANG Yifu;LANG Le;ZHANG Chenglong;ZHAO Lingyi;YANG Ruiqin(Beijing Municipal Key Laboratory of Forensic Science of People’s Public Security University of China,Beijing 100038,China;Jilin Province Product Quality Supervision and Inspection Institute,Changchun 130103,Jilin,China)

机构地区：[1]中国人民公安大学刑事科学技术北京市重点实验室,北京100038 [2]吉林省产品质量监督检验院,吉林长春130103

出　　处：《菌物学报》2024年第2期1-15,共15页Mycosystema

基　　金：刑事科学技术北京市重点实验室建设项目(2023ZB06);刘耀院士基金(YZ-2023001)。

摘　　要：鹅膏环肽类毒素主要存在于鹅膏属Amanita、盔孢伞属Galerina和环柄菇属Lepiota蘑菇中。如果不慎摄入,可能会给人类和动物带来严重的健康风险。快速准确地鉴定蘑菇和生物样品中的这些毒素对于确保食品安全以及诊断和治疗蘑菇中毒至关重要。本文综述了文献报道的各类检测方法,重点介绍高效液相色谱与质谱联用法,这是测定复杂基质中鹅膏肽类毒素的主要分析方法。此外,本文还提出了鹅膏环肽类毒素检测的当前趋势,并对未来现场快速检测及仪器定量检测进行了展望。Amanita cyclic peptide toxins are mainly found in mushrooms of genera Amanita,Galerina,and Lepiota,and probably pose serious health risks to humans and animals if they are ingested accidentally.Rapid and accurate identification of these toxins in mushrooms and biological samples is crucial for ensuring food safety and diagnosing and treating mushroom poisoning.This review discusses various reported detection methods,focusing on high-performance liquid chromatography coupled with mass spectrometry,which is the main analytical method for determining Amanita cyclic peptide toxins in complex matrices.Furthermore,current trends and future directions in the detection of Amanita cyclic peptide toxins are also presented.

关 键 词：蘑菇中毒 鹅膏环肽类毒素 检测技术 高效液相色谱质谱联用 

分 类 号：O652[理学—分析化学] D918.9[理学—化学]