耳穴综合疗法治疗月经性偏头痛患者临床疗效及对血清前列腺素的影响  

The curative efficacy of auricular comprehensive therapy on menstrual migraine and its effect on serum prostaglandin

作　　者：邵国梁[1] 黄绍磊 李瑞 杨佃会[2] 王萌萌 SHAO Guo-liang;HUANG Shao-lei;LI Rui;YANG Dian-hui;WANG Meng-meng(School of Acupuncture-moxibustion and Tuina,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Acupuncture and Moxibustion,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011)

机构地区：[1]山东中医药大学针灸推拿学院,济南250014 [2]山东中医药大学附属医院针灸科,济南250011

出　　处：《针刺研究》2024年第2期177-184,共8页Acupuncture Research

基　　金：山东省自然科学基金青年项目(No.ZR2020QH315)。

摘　　要：目的:观察耳穴综合疗法治疗月经性偏头痛(MM)的临床疗效及对血清前列腺素F2α(PGF_(2α))、前列腺素E_(2)(PGE_(2))含量、比值的影响,探讨其可能的作用机制。方法:将66例肝火旺盛型MM患者随机分为观察组(33例,脱落2例)和对照组(33例,脱落2例),并纳入20例健康女性作为正常组。对照组口服盐酸氟桂利嗪胶囊,每天2次,连续治疗3周;观察组予以耳穴综合疗法治疗,从月经来潮前2~5 d开始,1周治疗1次,共治疗3次。观察组与对照组分别于治疗前后及治疗后随访2个月经周期时以视觉模拟量尺(VAS)和偏头痛积分评价患者头痛程度,观察组、对照组和正常组分别于治疗前后测定月经期血清PGF_(2α)、PGE_(2)含量并计算PGF_(2α)/PGE_(2)比值,评定两组MM患者的临床疗效。结果:与治疗前比较,观察组与对照组患者治疗后及随访时VAS评分均明显降低(P<0.05),且观察组低于对照组(P<0.05)。与治疗前比较,观察组与对照组患者治疗后及随访时偏头痛积分中头痛发作次数、每次发作持续时间、头痛程度及伴随症状评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前观察组与对照组患者PGF_(2α)含量高于正常组(P<0.05),PGE_(2)含量低于正常组(P<0.05),PGF_(2α)/PGE_(2)比值高于正常组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGF_(2α)含量明显降低(P<0.05),且观察组低于对照组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGE_(2)含量明显升高(P<0.05),且观察组高于对照组(P<0.05);与治疗前比较,观察组与对照组患者治疗后血清PGF_(2α)/PGE_(2)比值均明显降低(P<0.05),且对照组较正常组明显升高(P<0.05),观察组较对照组明显降低(P<0.05)。观察组的临床有效率为93.5%(29/31),对照组的临床有效率为77.4%(24/31),观察组高于对照组(P<0.05)。结论:耳穴综合疗法治疗肝火旺盛型MM疗效明显优于口服盐酸氟桂利嗪胶囊,在Objective To observe the curative efficacy of auricular comprehensive therapy on menstrual migraine(MM)and its effect on serum prostaglandin F2α(PGF_(2α)),prostaglandin E2(PGE_(2))contents and ratio,so as to explore its possible mechanism.Methods A total of 66 patients with MM of liver-fire syndrome were randomly divided into observation group(33 cases,2 cases dropped off)and control group(33 cases,2 cases dropped off),and 20 healthy women were included in the normal group.Patients in the control group were given flunarizine hydrochloride capsules orally,twice a day,for 3 consecutive weeks.Patients in the observation group were treated with auricular comprehensive therapy,starting 2—5 days before menstrual cramps,once a week,for a total of 3 weeks.The visual analogue scale(VAS)and migraine score were evaluated before and after treatment,and follow-up for 1 and 2 menstrual cycles.Serum PGF_(2α)and PGE_(2) contents were measured before and after treatment,and the PGF_(2α)/PGE_(2) ratio was calculated.The clinical effective rates in the two groups were calculated.Results After treatment and follow-up for 1 and 2 menstrual cycles,the VAS scores,headache degree,the frequency and duration of headache attacks,as well as accompanying symptoms of the observation and control groups were lower than those before treatment(P<0.05),and those of the observation group was lower than those of the control group(P<0.05).Before treatment,the PGF_(2α)contents in the observation and control group were significantly higher(P<0.05),while the PGE_(2) contents lower(P<0.05)and PGF_(2α)/PGE_(2) ratio higher(P<0.05)than those in the normal group.After treatment,the serum PGF_(2α)contents in the observation and control group were significantly reduced compared with which before treatment(P<0.05),and were lower in the observation group than that in the control group(P<0.05).The serum PGE_(2) contents in the observation and control groups were significantly increased after treatment compared with which before treatment(P<0.05),with th

关 键 词：耳穴综合疗法 月经性偏头痛 前列腺素F2Α 前列腺素E2 

分 类 号：R246.3[医药卫生—针灸推拿学]