Total Synthesis of Syringin and Its Natural Analogues via C—C Bond Activation of Aryl Ketones  

作　　者：Zhen-Yu Wang Yi Sun Guo-Dong Sun Hui Xu Hui-Xiong Dai 

机构地区：[1]School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210023 China [2]CAS Key Laboratory of Receptor Research,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203 China [3]University of Chinese Academy of Sciences,Beijing,100049 China

出　　处：《Chinese Journal of Chemistry》2023年第24期3587-3592,共6页中国化学（英文版）

基　　金：supported by the Shanghai Institute of Materia Medica,the Chinese Academy of Sciences,the National Natural Science Foundation of China(21772211,21920102003);the Institutes for Drug Discovery and Development,Chinese Academy of Sciences(CASIMM0120163006);the Science and Technology Commission of Shanghai Miunicipality(17JC1405000,18431907100);the Program of Shanghai Academic Research Leader(19xD1424600);the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program",China(2018ZX09711002-006).

摘　　要：Syringin is found in the root of Acanthopanax senticosus(Rupr.Maxim.)Harms and belongs to the lignin chemical compound with many biological activities.In this study,we employed commercially available starting materials and accomplished the total synthesis of syringin in 5 steps with an overall yield of 58%.Palladium-catalyzed C(O)–C bond activation and subsequent cross coupling reaction is the key to construct syringin and its natural analogues.

关 键 词：SYRINGIN Total synthesis CROSS-COUPLING C—C activation Syringin analogues 

分 类 号：O62[理学—有机化学]