Recent Advances in Domino Synthesis of Fused Polycyclic N-Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis  

作　　者：Zefeng Jin Guodong Shen Xin Lv 

机构地区：[1]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,College of Chemistry and Materials Science,Zhejiang Normal University,Jinhua,Zhejiang,321004 China [2]School of Chemistry and Chemical Engineering,Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology,Liaocheng University,Liaocheng,Shandong,252059 China

出　　处：《Chinese Journal of Chemistry》2023年第24期3751-3771,共21页中国化学（英文版）

基　　金：financial supports from the Natural Science Foundation of Zhejiang Province(LY21B020005);the National Natural Science Foundation of China(21202152).

摘　　要：Fused polycyclic N-heterocycles are very important scaffolds in biomedicinal chemistry and materials science.Intramolecular alkyne hydroamination is a powerful method for the construction of N-heterocycles.In the last two decades,copper-catalyzed domino reactions based on intramolecular alkyne hydroamination has emerged as a robust strategy for assembling various fused polycyclic N-heterocycles.Great progress has been achieved in this area.This short review covers the advances made in copper-catalyzed domino synthesis of fused polycyclic N-heterocycles based on the strategy from 2008 to 2023,and will hopefully serve as an inspiration towards the exploration of new copper-catalyzed versions of the transformation.The domino transformations are introduced and discussed from five aspects according to the different key processes involved in these reactions.

关 键 词：Domino reactions Polycyclic N-heterocycles Fused-ring systems Intramolecular hydroamination ALKYNES Copper CYCLIZATION Synthetic methods 

分 类 号：O62[理学—有机化学]