Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin  

作　　者：Yueming Wu Yuan Chen Haowen Yu Alideertu Dong Runhui Liu 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237 China [2]Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237 China [3]Engineering Research Center of Dairy Quality and Safety Control Technology,Ministry of Education,Inner Mongolia University,Hohhot,Inner Mongolia,010021 China

出　　处：《Chinese Journal of Chemistry》2023年第23期3333-3338,共6页中国化学（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(Nos.52203162,22075078);Program of Shanghai Academic/Technology Research Leader(20xD1421400);China National Postdoctoral Program for Innovative Talents(Bx20220108);the China Postdoctoral Science Foundation(2021M701198);Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry(Changchun Institute of Applied Chemistry,Chinese Academy of Sciences),the Open Project of Engineering Research Center of Dairy Quality and Safety Control Technology(Ministry of Education,R202201);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission);Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization in this manuscript.

摘　　要：The intensive use of antibiotics intensifies the development of bacterial resistance,which has become a serious problem globally.Methicillin-resistant Staphylococcus aureus(MRSA)has resulted in significant morbidity and mortality.Therefore,it is an urgent need to develop new antimicrobial drugs and administration methods.Herein,we report a dual functional diblock copolymer PLL20-b-PBLG20,which was prepared by superfast and water-insensitive polymerization on N-carboxyanhydrides(NCA)initiated by tetraalkylammonium carboxylate.In addition to direct antimicrobial activity,PLL20-b-PBLG20 also exerts a synergistic bactericidal effect against MRSA with curcumin,a plant extract with antibacterial property.Moreover,PLL20-b-PBLG20 successfully encapsulates curcumin to form nanoparticles via self-assembly.The combination of dual functional PLL20-b-PBLG20 and curcumin holds promise in combating MRSA infections.

关 键 词：Amino acid polymer Antimicrobial Synergy ENCAPSULATION MRSA 

分 类 号：R284[医药卫生—中药学] O63[医药卫生—中医学]