Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles  

作　　者：Natalya V.Zakharova Stanislav N.Zelinskiy Mariya S.Strelova Elena N.Danilovtseva Vadim V.Annenkov 

机构地区：[1]Institute of Macromolecular Compounds of the Russian Academy of Sciences,Saint Petersburg,199004,Russia [2]Limnological Institute of Siberian Branch of the Russian Academy of Sciences,Irkutsk,664033,Russia

出　　处：《Chinese Journal of Polymer Science》2024年第4期437-445,共9页高分子科学（英文版）

基　　金：supported by the Russian Science Foundation(No.22-24-00474).

摘　　要：By the reaction of poly(acryloyl chloride) with N-(3-aminopropyl)imidazole, poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitive properties of the obtained sample were studied by1H-and13C-NMR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and viscometry. The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48℃ indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-DNA more actively than poly(1-vinylimidazole), which is of interest for gene delivery applications. The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface, and the modified surface is able to attach negatively charged objects. This thermo-and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.

关 键 词：Imidazole-containing polymer Thermolability PH-SENSITIVITY The modified surface DNA immobilization 

分 类 号：TQ317[化学工程—高聚物工业]