补肾化瘀方对PCOS患者血清半乳糖凝集素-3、IL-6及CRP水平的影响  

Effect of Bushen Huayu Decoction on serum galectin-3,IL-6 and CRP levels in patients with PCOS

作　　者：汪钘 梅青青 潘敏丹 孙忻[4] WANG Xing;MEI Qing-qing;PAN Min-dan;SUN Xin(The Second Clinical College of Zhejiang Chinese Medicine University,Hangzhou,Zhejiang 310053,China;Department of Traditional Chinese Medicine,The Third People's Hospital of Yueqing,Wenzhou,Zhejiang 325604,China;Department of Gynecology of TCM,Ninghai Maternal and Child Health Hospital,Ningbo,Zhejiang 315600,China;Department of Reproductive Medicine,Zhejiang Hospital of Integrated Traditional and Western Medicine,Hangzhou,Zhejiang 310003,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江省乐清市第三人民医院中医科,温州325604 [3]浙江省宁海县妇幼保健院中医妇科,宁波315600 [4]浙江省中西医结合医院生殖医学科,杭州310003

出　　处：《浙江中西医结合杂志》2024年第3期224-229,共6页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：浙江省中医药科学研究基金项目(No.2020ZB181、2022ZB267)。

摘　　要：目的 探讨补肾化瘀方治疗肾虚血瘀型多囊卵巢综合征(PCOS)患者的临床疗效及可能的作用机制。方法 将2020年9月至2021年9月期间,首次就诊于浙江省中西医结合医院生殖医学科门诊的60例肾虚血瘀型PCOS患者按照随机数字表法分为对照组和治疗组,各30例。对照组给予二甲双胍治疗,治疗组给予补肾化瘀方治疗,两组均治疗3个月经周期。观察治疗前后中医证候积分、性激素、糖脂代谢相关指标及半乳糖凝集素-3(Galectin-3)、白介素6(IL-6)、C反应蛋白(CRP)水平的变化情况。结果 治疗前,两组患者性激素、糖代谢相关指标、脂代谢相关指标、炎症因子水平比较,差异无统计学意义(P>0.05)。治疗后,治疗组PCOS患者排卵率较对照组高(76.83%比49.43%,P<0.01)。与治疗前相比,两组患者中医证候积分[(4.18±2.58)分比(12.50±2.17)分,(6.07±2.94)分比(11.97±2.44)分,P<0.01]、空腹血糖[(5.05±0.45)mmol/L比(5.27±0.70)mmol/L,(4.92±0.56)mmol/L比(5.44±0.37)mmol/L,P<0.05]、空腹胰岛素[(9.66±4.54)mU/L比(13.48±4.73)mU/L,(8.44±2.81)mU/L比(12.20±5.19)mU/L,P<0.05]及胰岛素抵抗指数[(2.18±1.05)比(3.17±1.24),(1.89±0.76)比(2.99±1.42),P<0.05]降低。与对照组比较,治疗组中医证候积分降低[(4.18±2.58)分比(6.07±2.94)分,P<0.05],黄体生成素[(10.12±1.72)mIU/mL比(12.54±2.56)mIU/mL,P<0.05]、黄体生成素/卵泡刺激素[(1.65±0.32)比(1.95±0.40),P<0.05]、睾酮[(0.47±0.12)ng/mL比(0.57±0.16)ng/mL,P<0.05]水平降低,三酰甘油[(1.31±0.62)mmol/L比(1.66±0.56)mmol/L,P<0.05]、总胆固醇[(3.91±0.98)mmol/L比(4.40±0.70)mmol/L,P<0.05]、低密度脂蛋白[(2.60±0.61)mmol/L比(3.05±0.79)mmol/L,P<0.05]水平降低,高密度脂蛋白水平升高[(1.41±0.17)mmol/L比(1.31±0.17)mmol/L,P<0.05]。与对照组比较,治疗组Galectin-3 [(8.71±1.67)ng/mL比(9.91±2.23)ng/mL,P<0.05]、IL-6 [(30.24±3.85)pg/mL比(32.62±4.97)pg/mL,P<0.05]、CRP[(2.80±0.91)mg/L比(3.32±0.64)mg/L,P<0.05]水平降�Objective To investigate the clinical efficacy and possible mechanism of Bushen Huayu Decoction in treating patients with polycystic ovary syndrome(PCOS)of kidney deficiency and blood stasis pattern.Methods From September 2020 to September 2021,60 patients with PCOS of kidney deficiency and blood stasis pattern who were first treated at the Department of Reproductive Medicine,Zhejiang Hospital of Integrated Traditional and Western Medicine were enrolled.These patients were randomly divided into control and treatment groups,with 30 patients in each group.The control group received metformin treatment,while the treatment group received Bushen Huayu Decoction treatment for a duration of 3 menstrual cycles.Changes in Traditional Chinese Medicine(TCM)syndrome scores,sex hormones,glycolipid metabolism related indicators,as well as the levels of Galectin-3,interleukin-6(IL-6)and C-reactive protein(CRP)were assessed before and after treatment.Results There were no statistically significant differences in the baseline levels of sex hormones,glucose metabolism related indicators,lipid metabolism related indicators and inflammatory factors between the two groups(P>0.05).After treatment,the ovulation rate of PCOS patients in the treatment group was higher than that in the control group(76.83 vs.49.43%,P<0.01).Compared to baseline,both groups showed decreased TCM syndrome scores(4.18±2.58 vs.12.50±2.17,6.07±2.94 vs.11.97±2.44,P<0.01),as well as fasting blood glucose(5.05±0.45 vs.5.27±0.70 mmol/L,4.92±0.56 vs.5.44±0.37 mmol/L,P<0.05),fasting insulin(9.66±4.54 vs.13.48±4.73 mU/L,8.44±2.81 vs.12.20±5.19 mU/L,P<0.05)and homeostasis model assessment of insulin resistance(2.18±1.05 vs.3.17±1.24,1.89±0.76 vs.2.99±1.42,P<0.05).Compared to the control group,the treatment group showed reductions in TCM syndrome scores(4.18±2.58 vs.6.07±2.94,P<0.05),luteinizing hormone(10.12±1.72 vs.12.54±2.56 mIU/mL,P<0.05),luteinizing hormone/follicle stimulating hormone(1.65±0.32 vs.1.95±0.40,P<0.05),testosterone(0.47±0.12 vs.0

关 键 词：多囊卵巢综合征 补肾化瘀方 慢性炎症 半乳糖凝集素-3 白介素-6 

分 类 号：R259[医药卫生—中西医结合]