盐酸艾司氯胺酮注射液静脉输注联合常规静脉全身麻醉在小儿斜视矫正术中的应用效果  

Application effects of intravenous infusion of Esketamine hydrochloride injection combined with conventional intravenous general anesthesia in children with strabismus correction surgery

作　　者：葛晓丹 刘伟伟[1] 鲁海兵 贾英萍 GE Xiaodan;LIU Weiwei;LU Haibing;JIA Yingping(Department of Anesthesiology and Perioperative Medicine,Children's Hospital Affiliated of Zhengzhou University,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州大学附属儿童医院麻醉与围术期医学科,河南郑州450000

出　　处：《中国民康医学》2024年第5期76-78,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸艾司氯胺酮注射液静脉输注联合常规静脉全身麻醉在小儿斜视矫正术中的应用效果。方法:选取2022年4月至2023年4月该院收治的100例行小儿斜视矫正术的患儿进行前瞻性研究,按照随机数字表法分为观察组与对照组各50例。对照组采用常规静脉全身麻醉,观察组在对照组基础上联合盐酸艾司氯胺酮注射液静脉输注麻醉,比较两组不同时间[麻醉前(T_(1))、麻醉后5 min(T_(2))、开始矫正时(T_(3))、术毕(T_(4))]平均动脉压、心率,手术时间、术后意识恢复时间、苏醒期躁动发生率,不同时间(术后2、12、24 h)面部表情疼痛量表(FPS-R)评分,以及不良反应发生率。结果:T_(2)、T_(3)、T_(4)时,两组平均动脉压、心率均高于T_(1)时,但观察组低于对照组,差异有统计学意义(P<0.05);观察组苏醒期躁动发生率为4.00%,低于对照组的18.00%,差异有统计学意义(P<0.05);术后2、12、24 h,观察组FPS-R评分均低于对照组,差异有统计学意义(P<0.05);两组手术时间、术后意识恢复时间和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:盐酸艾司氯胺酮注射液静脉输注联合常规静脉全身麻醉用于小儿斜视矫正术中可降低患儿苏醒期躁动发生率、平均动脉压、心率以及FPS-R评分,效果优于单纯常规静脉全身麻醉。Objective:To observe application effects of intravenous infusion of Esketamine hydrochloride injection combined with conventional intravenous general anesthesia in children with strabismus correction surgery.Methods:A prospective study was conducted on 100 children who underwent strabismus correction in this hospital from April 2022 to April 2023.According to the random number table method,they were divided into observation group and control group,50 cases in each group.The control group was treated with routine intravenous general anesthesia,while the observation group was treated with intravenous infusion of Esketamine hydrochloride injection on the basis of that of the control group.The mean arterial pressure(MAP)and the heart rate(HR)at different time[before anesthesia(T_(1)),5 min after anesthesia(T_(2)),beginning correction(T_(3)),end of surgery(T_(4))],the operation time,the postoperative consciousness recovery time,the incidence of agitation during recovery period,the faces pain scale-revised(FPS-R)scores at different time(2,12,24 h after the surgery)and the incidence of adverse reactions were compared between the two groups.Results:At T_(2),T_(3) and T_(4),the levels of mean arterial pressure and heart rate of the two groups were higher than those at T_(1),but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of agitation during the recovery period in the observation group was 4.00%,which was lower than 18.00%in the control group,and the difference was statistically significant(P<0.05).At 2,12 and 24 h after the surgery,the FPS-R scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the operation time,the postoperative consciousness recovery time and the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Intravenous infusion of Esketamine hydrochloride injecti

关 键 词：艾司氯胺酮 全身麻醉 小儿斜视矫正术 躁动 平均动脉压 心率 FPS-R评分 

分 类 号：R614[医药卫生—麻醉学]