药物涂层球囊与雷帕霉素洗脱支架治疗冠状动脉小血管病变患者的效果比较  

Comparison of effects of drug-coated balloon and Rapamycin-eluting stent in treatment of patients with coronary small vessel disease

作　　者：仇庆华[1] 黄兰薰 常青 郭艾武[1] QIU Qinghua;HUANG Lanxun;CHANG Qing;GUO Aiwu(Department of Cardiology of Ruici Hospital,Nantong 226300 Jiangsu,China)

机构地区：[1]南通瑞慈医院心内科,江苏南通226300

出　　处：《中国民康医学》2024年第5期153-155,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较药物涂层球囊与雷帕霉素洗脱支架治疗冠状动脉小血管病变患者的效果。方法:选取2021年3月至2022年2月该院收治的60例冠状动脉小血管病变患者进行前瞻性研究,依据随机数字表法将其分为对照组与研究组各30例。两组均接受经皮冠状动脉介入治疗,对照组植入雷帕霉素洗脱支架,研究组使用药物涂层球囊治疗,术后随访1年。比较两组术前、术后即刻、术后1年时病变血管最小管腔直径(MLD)和狭窄程度,晚期管腔丢失情况以及并发症发生率。结果:术后即刻,两组MLD均大于术前,狭窄程度均低于术前,但组间比较差异均无统计学意义(P>0.05);术后1年,两组MLD均小于术后即刻,狭窄程度均高于术后即刻,但研究组MLD大于对照组,狭窄程度低于对照组,差异有统计学意义(P<0.05);术后1年,研究组晚期管腔丢失小于对照组,差异有统计学意义(P<0.05);研究组并发症发生率为13.33%(4/30),低于对照组的36.67%(11/30),差异有统计学意义(P<0.05)。结论:药物涂层球囊治疗冠状动脉小血管病变患者近期疗效与雷帕霉素洗脱支架相当,但远期疗效更好,术后1年时MLD更大、狭窄程度更低,可减少晚期管腔丢失,降低支架内血栓形成、再狭窄等并发症发生率。Objective:To observe and analyze application effects of drug-coated balloon and Rapamycin-eluting stent in treatment of patients with coronary small vessel disease.Methods:A prospective study was conducted on 60 patients with coronary small vessel disease admitted to the hospital from March 2021 to February 2022.According to the random number table method,they were divided into control group and study group,30 cases in each group.Both groups were received percutaneous coronary intervention.The control group was implanted with Rapamycin-eluting stents,while the study group was treated with drug-coated balloon.All patients were followed up for 1 year.The minimum lumen diameter(MLD)and diameter stenosis the before the surgery,immediately and 1 year after the surgery,the late lumen loss,and the incidence of complications were compared between the two groups.Results:Immediately after the surgery,the MLD of the two groups were higher than those before the surgery,and the diameter stenosis were lower than those before the surgery,however,there were no significant differences between the two groups(P>0.05).One year after the surgery,the MLD of the two groups were lower than those immediately after the surgery,and the diameter stenosis were higher than those immediately after the surgery;however,the MLD of the study group was greater than that of the control group,and the diameter stenosis was lower than that of the control group;and the differences were statistically significant(P<0.05).One year after the surgery,the late lumen loss in the study group was smaller than that in the control group,and the difference was statistically significant(P<0.05).Further,the incidence of complications in the study group was 13.33%(4/30),which was lower than 36.67%(11/30)in the control group,and the difference was statistically significant(P<0.05).Conclusions:The short-term efficacy of drug-coated balloon in the treatment of the patients with coronary small vessel disease is similar to that of Rapamycin-eluting stent,but the long-term

关 键 词：雷帕霉素 药物洗脱支架 药物涂层球囊 冠状动脉小血管病变 再狭窄 远期疗效 

分 类 号：R541.4[医药卫生—心血管疾病]