血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性  

The Correlation between Serum Myocardial Injury Markers and Inflammatory Factors with the Severity of Neonatal Asphyxia

作　　者：沈洁 张卫星 武俊宝 SHEN Jie;ZHANG Weixing;WU Junbao(Neonatal Intensive Care Unit,Xinxiang Medical University,Xinxiang Central Hospital,Xinxiang Henan 453000)

机构地区：[1]新乡市中心医院/新乡医学院第四临床学院新生儿重症监护室,河南新乡453000

出　　处：《医学临床研究》2024年第2期273-275,279,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性。【方法】选择2019年9月至2022年9月在本院出生的120例新生儿窒息患儿(观察组)及50例健康新生儿(对照组)。比较两组研究对象血清心肌损伤标志物[肌钙蛋白I(cTnI)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)]及炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)],并分析血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平与新生儿窒息严重程度关系。【结果】观察组患儿血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平均高于对照组,差异有统计学意义(P<0.05)。重度窒息组患儿出生第1天及第7天血清cTnI、CK、CK-MB水平高于轻度窒息组(P<0.05),两组出生第7天血清cTnI、CK、CK-MB水平低于出生第1天,差异有统计学意义(P<0.05)。重度窒息组患儿出生第1天及第7天血清CRP、IL-6、TNF-α水平均明显高于轻度窒息组(P<0.05),两组患儿出生第7天血清CRP、IL-6、TNF-α水平低于出生第1天,差异有统计学意义(P<0.05)。Spearman相关性分析显示,血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平与新生儿窒息严重程度均呈正相关(均P<0.05)。【结论】新生儿窒息患儿的心肌损伤标志物及炎症因子水平异常升高,且心肌损伤标志物及炎症因子水平与新生儿窒息严重程度呈正相关。【Objective】To explore the correlation between serum myocardial injury markers and inflammatory factors with the severity of neonatal asphyxia.【Methods】A total of 120 newborns with asphyxia born in our hospital from September 2019 to September 2022(observation group)and 50 healthy newborns(control group)were selected.Two groups of study subjects were compared in terms of serum myocardial injury biomarkers[calcin I(cTnI),creatine kinase(CK),and creatine kinase isoenzyme(CK-MB)]and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],and the relationship between serum cTnI,CK,CK-MB,CRP,IL-6,TNF-αlevels and the severity of neonatal asphyxia was analyzed.【Results】The serum levels of cTnI,CK,CK-MB,CRP,IL-6,and TNF-αin the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of cTnI,CK,and CK-MB in the severe asphyxia group were higher than those in the mild asphyxia group on the 1st and 7th day of birth(P<0.05),and the serum levels of cTnI,CK,and CK-MB on the 7th day of birth were lower than those on the 1st day of birth in the two groups,with statistical significance(P<0.05).The serum levels of CRP,IL-6,and TNF-αin the severe asphyxia group were significantly higher than those in the mild asphyxia group on the 1st and 7th day of birth(P<0.05).The serum levels of CRP,IL-6,and TNF-αin the two groups were lower on the 7th day of birth than on the 1st day of birth,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that serum levels of cTnI,CK,CK-MB,CRP,IL-6,TNF-αwere positively correlated with the severity of neonatal asphyxia(all P<0.05).【Conclusion】The levels of myocardial injury markers and inflammatory factors in newborns with asphyxia are abnormally elevated,and the levels of myocardial injury markers and inflammatory factors are positively correlated with the severity of neonatal asphyxia.

关 键 词：新生儿窒息 肌钙蛋白/血液 肌酸激酶 MB型/血液 炎症趋化因子类/血液 

分 类 号：R722.12[医药卫生—儿科]