慢性肾脏病5期非透析患者同型半胱氨酸与腹主动脉钙化的相关性  

Correlation between homocysteine and abdominal aortic calcification in non-dialysis patients with stage 5 chronic kidney disease

作　　者：杨星梦 马晓迎[1] 生玉平 刘烨 张浩然[1] 徐海平[1] 王娜[1] 孙福云[1] Yang Xingmeng;Ma Xiaoying;Sheng Yuping;Liu Ye;Zhang Haoran;Xu Haiping;Wang Na;Sun Fuyun(Department of Nephrology,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市中心医院肾内科,河北沧州061000

出　　处：《临床荟萃》2024年第1期30-33,共4页Clinical Focus

基　　金：2022年度河北省医学科学研究课题计划——腹主动脉钙化及miR-204与终末期肾脏病患者预后的相关分析(20220332);2022年沧州市自然科学基金项目——DNMTs在慢性肾脏病血管钙化中的机制研究(221001006D)。

摘　　要：目的 评估慢性肾脏病(chronic kidney disease, CKD)患者同型半胱氨酸(homocysteine, Hcy)水平和腹主动脉钙化(abdominal aortic calcification,AAC)情况,探讨Hcy水平与CKD患者AAC的相关性。方法 选取2019年12月1日至2022年12月1日就诊于沧州市中心医院肾内科的CKD患者291例,通过侧卧位腹平片评估AAC情况后,分为钙化组(n=140)和非钙化组(n=151)。记录两组一般资料及Hcy水平,分析Hcy水平与CKD患者AAC的相关性。结果 钙化组Hcy水平高于非钙化组,差异有统计学意义(P<0.05)。多因素Logistic回归分析提示,Hcy升高(P<0.01,OR=1.033, 95%CI=1.016~1.051)是CKD患者发生AAC的独立危险因素之一。结论高Hcy是CKD患者AAC的独立危险因素之一。Objective To evaluate the levels of homocysteine(Hcy)and abdominal aortic calcification(AAC)in patients with chronic kidney disease(CKD),and to explore the correlation between Hcy levels and AAC in CKD patients.Methods A total of 291 CKD patients who visited the Department of Nephrology at Cangzhou Central Hospital from December 1,2019 to December 1,2022 were selected.They were assigned into a calcified group(n=140)and a non calcified group(n=151)according to the evaluating results of lateral abdominal X-ray for AAC.The general information and Hcy levels were recorded between groups,and the correlation between Hcy levels and the occurrence of AAC in CKD patients was analyzed.Results The Hcy level in the calcified group was significantly higher than that of the non calcified group(P<0.05).Multivariate Logistic regression analysis suggests that elevated Hcy(OR=1.033,95%CI:1.016-1.051,P<0.01)was one of the independent risk factors for the occurrence of AAC in CKD patients.Conclusion High Hcy is one of the independent risk factors for the occurrence of AAC in CKD patients.

关 键 词：慢性肾脏病 同型半胱氨酸 腹主动脉钙化 

分 类 号：R692[医药卫生—泌尿科学]