355 nm激光应用于血栓及其钙化组织消融的实验研究  

Experiment and research on the ablation of thrombus and calcified tissue with 355 nm laser

作　　者：李珉澄 姚育成[1,2] 张奥 鲁志兵 胡玥 邓晓月[1] 张泽 LI Mincheng;YAO Yucheng;ZHANG Ao;LU Zhibin;HU Yue;DENG Xiaoyue;ZHANG Ze(School of Science,Hubei University of Technology,Wuhan 430068,China;Hubei Engineering Technology Research Center of Energy Photoelectric Device and System,Hubei University of Technology,Wuhan 430068,China;artment of Cardiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Institute of Myocardial Injury and Repair,Wuhan University,Wuhan 430072,China)

机构地区：[1]湖北工业大学理学院,武汉430068 [2]湖北省能源光电器件与系统工程技术研究中心,武汉430068 [3]武汉大学中南医院心血管内科,武汉430071 [4]武汉大学心肌损伤与修复研究所,武汉430072

出　　处：《激光杂志》2024年第2期197-202,共6页Laser Journal

基　　金：武汉市科技计划项目(No.2020BED021)。

摘　　要：相较于308 nm准分子激光器,355 nm脉冲固体激光器在峰值功率、成本和方便性等方面更具优势,使用离体新鲜猪血凝块与新鲜鸡胫骨块作为类血栓及其钙化组织,研究355 nm脉冲固体激光的组织消融特性及规律。实验结果显示:组织消融孔洞形貌良好,无颗粒沉积;消融后微粒直径均在10微米量级,处于人体可自然代谢的范围,且25 mJ~200 mJ范围内脉冲能量越小,消融后微粒越小;灌注条件下,热影响区组织温升小于4.5℃,不会对血管壁造成热损伤。故355 nm脉冲固体激光可有效消融血栓及其钙化组织,具有较好应用前景。Compared with 308 nm excimer laser,355 nm pulsed solid laser has more advantages in terms of peak power,cost and convenience.Fresh pig blood clot and fresh chicken tibia block were used as thromboid and calcified tissue to study the tissue ablation characteristics and rules of 355 nm pulsed solid laser.The experimental results show that the morphology of tissue ablation holes is good and there is no particle deposition;The diameter of particles after ablation is 10 microns,which is in the range of natural metabolism of human body,and the smaller the pulse energy is in the range of 25 mJ~200 mJ,the smaller the particles after ablation;Under perfusion conditions,the tissue temperature rise in the heat-affected zone is less than 4.5℃,which will not cause thermal damage to the vessel wall.Therefore,355 nm pulsed solid laser can effectively ablate thrombus and calcified tissue,and has a good application prospect.

关 键 词：355 nm激光 消融 血栓及其钙化组织 脉冲能量 微粒尺寸 温升 

分 类 号：TN29[电子电信—物理电子学]