右颈动脉狭窄和不同冠状动脉病变支数老年冠心病患者血清IP-10、LHP、TNF-α水平变化及临床意义  

Changes and Clinical Significance of Serum IP-10,LHP and TNF-α in Elderly Patients with CHD,Right Carotid Stenosis and Different Number of Diseased Coronary Vessels

作　　者：张翥 范修才 祁建成 吴景盛 ZHANG Zhu;FAN Xiucai;QI Jiancheng;WU Jingsheng(Department of Cardiovascular Medicine,Jianhu Clinical Medical College,Yangzhou University,Yangzhou 224700,China)

机构地区：[1]扬州大学建湖临床医学院心血管内科,江苏扬州224700

出　　处：《中国分子心脏病学杂志》2023年第6期5749-5753,共5页Molecular Cardiology of China

基　　金：盐城市科技计划项目(YK2021082)。

摘　　要：目的 探讨右颈动脉狭窄和不同冠脉病变老年冠心病(coronary heart disease,CHD)患者血清干扰素诱导蛋白-10(interferon inducible protein-10,IP-10)、脂质过氧化氢(lipid hydroperoxide,LHP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平变化及临床意义。方法 选取2021年10月至2022年10月收治的300例老年CHD患者(CHD组)和150例健康志愿(health control,HC)者(HC组),根据冠脉病变支数和CT血管造影将CHD组分为单支病变117例,双支病变101例,多支病变82例和狭窄组47例、非狭窄组253例。采用Spearman相关性分析血清IP-10、LHP、TNF-α水平与多支冠脉病变的关系;受试者操作特征(receiver operator characteristic,ROC)曲线分析血清IP-10、LHP、TNF-α水平并预测右颈动脉狭窄的价值。结果 CHD组血清IP-10、LHP、TNF-α水平高于HC组(P <0.05);多支冠脉病变患者血清IP-10、LHP、TNF-α水平高于单支和双支冠脉病变(P <0.05);Spearman相关性结果显示,血清IP-10、LHP、TNF-α水平与多支冠脉病变呈正相关(P <0.05);右颈动脉狭窄组血清IP-10、LHP、TNF-α水平高于非右颈动脉狭窄组(P <0.05);ROC曲线结果显示,血清IP-10、LHP、TNF-α水平诊断老年CHD患者右颈动脉狭窄的曲线下面积(area under curve,AUC)分别为0.890、0.708和0.814(P <0.05)。结论 右颈动脉狭窄和多支冠脉病变老年CHD患者血IP-10、LHP、TNF-α水平呈现显著增高趋势,血IP-10、LHP、TNF-α水平与与患者冠脉病变呈正相关,且可作为临床评估预测右颈动脉狭窄的指标。Objective To explore the changes and clinical significance of serum interferon-inducible protein-10(IP-10),lipid hydroperoxide(LHP) and tumor necrosis factor-α(TNF-α) in elderly patients with coronary heart disease(CHD),right carotid stenosis and different coronary lesions.Methods A total of 300 elderly patients with CHD(CHD group) and 150 healthy controls(HC group) admitted to our hospital between October 2021 and October 2022 were enrolled.According to the number of coronary lesions and results of CT angiography,patients in CHD group were divided into single vessel group(117 cases),double vessel group(101 cases) and multiple vessel group(82 cases),stenosis group(47 cases) and non-stenosis group(253 cases).The relationship between serum IP-10,LHP,TNF-α and multi-vessel coronary disease was analyzed by Spearman correlation analysis.The predictive value of IP-10,LHP and TNF-α for right carotid stenosis was analyzed by receiver operating characteristic(ROC) curves.Results The levels of serum IP-10,LHP and TNF-α in CHD group were higher than those in HC group(P <0.05),which were higher in patients with multi-vessel coronary disease than single-vessel and double-vessel disease(P<0.05).Spearman correlation analysis showed that levels of serum IP-10,LHP and TNF-α were positively correlated with multi-vessel coronary disease(P<0.05).The levels of serum IP-10,LHP and TNF-α in stenosis group were higher than those in non-stenosis group(P <0.05).ROC curves analysis showed that area under the curve(AUC) values of serum IP-10,LHP and TNF-α in the diagnosis of right carotid stenosis were 0.890,0.708 and 0.814,respectively(P<0.05).Conclusion In elderly patients with CHD,levels of serum IP-10,LHP and TNF-α significantly increase in those with right carotid stenosis and multi-vessel coronary disease.The three serum indexes are positively correlated with coronary lesions,which can be applied as clinical evaluation indexes for right carotid stenosis.

关 键 词：冠状动脉病变 右颈动脉狭窄 老年冠心病 干扰素诱导蛋白-10 脂质过氧化氢 肿瘤坏死因子-α 

分 类 号：R541.4[医药卫生—心血管疾病]