主动脉夹层中表观遗传调节血管平滑肌细胞表型转换的研究进展  

Epigenetics Modulation of Vascular Smooth Muscle Cell Phenotype in Aortic Dissection

作　　者：陈鸿 柏本健[1] CHEN Hong;BAI Benjian(Department of Cardiovascular Surgery,The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学第二附属医院心血管外科,咸阳市712000

出　　处：《中国分子心脏病学杂志》2023年第6期5822-5827,共6页Molecular Cardiology of China

摘　　要：主动脉夹层的发生发展与中层血管平滑肌细胞表型转换密切相关。表观遗传学通过DNA甲基化、组蛋白修饰、非编码RNA等,调节靶基因转录表达,参与血管平滑肌细胞表型的调控,促进或改善主动脉夹层。本文对主动脉夹层中表观遗传学对血管平滑肌细胞表型调控的相关研究进行综述。The development of aortic dissection is closely related to the phenotype of vascular smooth muscle cells.Epigenetics regulates the transcription and expression levels of target genes through DNA methylation,non-coding RNAs,and histone modifications,which are involved in the regulation of vascular smooth muscle cell phenotype and promote or improve the progress of aortic dissection.This review focuses on the studies of epigenetics modulation of vascular smooth muscle cells phenotype in aortic dissection.

关 键 词：主动脉夹层 血管平滑肌细胞 表型转换 表观遗传学 

分 类 号：R543.1[医药卫生—心血管疾病]