泛素特异性蛋白酶在病毒感染中的作用  

The role of ubiquitin-specific proteases in viral infection

作　　者：郭玉强 戴宗茂 黄晶晶[1] 王燕[1] Guo Yuqiang;Dai Zongmao;Huang Jingjing;Wang Yan(Department of Microbiology,Harbin Medical University,Harbin 150081,China;Clinical Laboratory of People's Hospital of Changshou Chongqing,Chongqing 400000,China)

机构地区：[1]哈尔滨医科大学微生物学教研室,哈尔滨150081 [2]重庆市长寿区人民医院检验科,重庆400000

出　　处：《国际免疫学杂志》2023年第6期662-666,共5页International Journal of Immunology

基　　金：国家自然科学基金(81772188);黑龙江省自然科学基金(LH2022H049)。

摘　　要：生物体内的泛素化水平通过泛素化酶(泛素激活酶E1、泛素结合酶E2、泛素连接酶E3)和去泛素化酶(deubiquitinating enzymes,DUBs)来平衡。其中泛素特异性蛋白酶(ubiquitin-specific proteases,USPs)是去泛素化酶家族中最大的亚类,也是细胞内蛋白质降解的重要参与者。USPs通过水解底物蛋白上的泛素分子从而影响或调节多种细胞活动,包括:基因转录、细胞周期调控、免疫应答、细胞受体功能以及肿瘤生长、炎症过程等。文章对USPs家族部分成员在多种生命活动中的作用做了归纳和总结,进一步为USPs在病毒感染中的研究提供参考。Ubiquitination level in organisms is balanced by ubiquitinating enzymes(E1,E2 and E3)and deubiquitinating enzymes(DUBs).Specifically,ubiquitin-specific proteases(USPs)are the major subclass of deubiquitinase family and critical participant in the processes of intracellular protein degradation.USPs affect or regulate a variety of cell activities,including gene transcription,cell cycle regulation,immune response,cell receptor function,tumor growth and inflammation process through hydrolyzing ubiquitin molecules that combine on substrate proteins.This review summarizes the role of several USPs family members in viral infections,and provided a prospect for further study.

关 键 词：泛素特异性蛋白酶 病毒感染 去泛素化 泛素 

分 类 号：R511[医药卫生—内科学]