组胺不耐受的研究进展  

Progress in the study of histamine intolerance

作　　者：蒋淑怡 曹鹏 许文静 张理涛[2] Jiang Shuyi;Cao Peng;Xu Wenjing;Zhang Litao(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Dermatological Department,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]天津市中医药研究院附属医院皮肤科,天津300120

出　　处：《国际免疫学杂志》2023年第6期679-683,共5页International Journal of Immunology

基　　金：国家自然科学基金(82305259)。

摘　　要：组胺是一种生物活性胺,不仅存在于人体中有着重要的生理功能,且普遍存在于日常摄入的食物中。外源性摄入的组胺主要由二胺氧化酶进行代谢。体内外源性组胺累积量与组胺代谢能力不平衡则引发组胺不耐受。组胺不耐受在临床中症状表现具有非特异性,可涉及皮肤病、胃肠道疾病、呼吸系统和神经系统疾病。食物、药物等因素会加重其症状。由于其临床表现累及多个系统,因此不易诊断常被忽略。近年来,组胺不耐受引发了研究者们的关注,而其病因、诊断及治疗方面仍需要继续研究探讨,因此对组胺不耐受的病因、诊断、治疗等方面的研究进展进行综述。Histamine is a bioactive amine which not only exists in the human body with important physiological functions,but is also commonly found in daily ingested foods.Exogenous histamine is mainly metabolized by diamine oxidase.Histamine intolerance is caused by an imbalance between the accumulation of exogenous histamine and the ability to metabolize histamine.The clinical manifestations of histamine intolerance are nonspecific and can include dermatologic,gastrointestinal,respiratory,and neurologic disorders.Symptoms can be exacerbated by food,medications,and other factors.The clinical manifestations of histamine intolerance are not easy to diagnose and are often overlooked since they involve multiple systems.In recent years,histamine intolerance has attracted the attention of researchers,and its etiology,diagnosis and treatment still need to be investigated.Accordingly,this article summarizes the progress of research on the etiology,diagnosis,and treatment of histamine intolerance.

关 键 词：组胺不耐受 二胺氧化酶 组胺 低组胺饮食 外源性组胺补充剂 

分 类 号：R597[医药卫生—内科学]