免疫血栓形成机制及相关研究进展  

The mechanism of immune thrombosis and related research progress

作　　者：蒋佳维 杨蕊 包佳婷 张会红 高红梅[1,2] Jiang Jiawei;Yang Rui;Bao Jiating;Zhang Huihong;Gao Hongmei(Department of Critical Care Medicine,Tianjin First Central Hospital,Tianjin 300192,China;Key Laboratory for Critical Care Medicine of the Ministry of Health,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院重症医学科,天津300192 [2]国家卫生健康委危重病急救医学重点研究室,天津300192

出　　处：《中国中西医结合急救杂志》2023年第6期749-754,共6页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：天津市医学重点学科(专科)建设项目资助(TJYXZDXK-013A);天津市科技计划项目(21JCYBJC0090);天津市卫生健康科技项目(ZC20012)。

摘　　要：免疫血栓形成是指由血管内(特别是微血管内)血栓形成引起的先天免疫反应.免疫血栓形成与免疫细胞和特定的血栓形成相关分子有关,产生血管内支架,促进病原体的识别、抑制和破坏,从而保护宿主的完整性.但免疫血栓形成的异常或不受控制的激活可能对宿主有害,是多种感染性和炎症相关血栓性疾病的基础.因此,了解免疫血栓形成的潜在机制对于开发更有效的方法来治疗和预防血栓形成具有决定性作用.本文概述了有关免疫血栓形成的机制,以便了解降低免疫血栓形成风险的新治疗策略.Immunothrombosis refers to the innate immune response caused by thrombosis in blood vessels(especially microvessels).Immunothrombosis is related to immune cells and specific thrombosis related molecules,producing intravascular scaffolds that promote pathogen recognition,inhibition,and destruction,thereby protecting the integrity of the host.However,abnormal or uncontrolled activation of immunothrombosis may be harmful to the host and serve as the foundation for various infectious and inflammatory related thrombotic diseases.Therefore,understanding the potential mechanisms of immunothrombosis plays a decisive role in developing more effective therapies for thrombosis treatment and prevention.This review provides an overview of the mechanisms of immunothrombosis in order to understand new treatment strategies for reducing the risk of immunothrombosis.

关 键 词：免疫血栓形成 中性粒细胞胞外诱捕网 血小板 

分 类 号：R459.7[医药卫生—急诊医学]