NLRP3炎性小体在器官移植不良反应发病机制中的研究进展  

Review of research progress on the role of NLRP3 inflammasome in the pathogenesis of adverse reactions of organ transplantation

作　　者：季媛 魏巴金[2] Ji Yuan;Wei Bajin(Operating Room,Jiangxi Cancer Hospital,Nanchang 330000,China;Key Laboratory of Combined Multi-Organ Transplantation,Ministry of Public Health,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]江西省肿瘤医院手术室,南昌330000 [2]浙江大学医学院附属第一医院卫健委多器官联合移植研究重点实验室,杭州310003

出　　处：《中华移植杂志（电子版）》2023年第5期308-312,共5页Chinese Journal of Transplantation(Electronic Edition)

基　　金：江西省卫生健康委科技计划项目(202211007)。

摘　　要：器官移植会产生诸多与炎症相关的不良反应。NLRP3是固有免疫系统中调控炎症反应的重要分子,在肝、肾等器官移植术后发生的缺血再灌注损伤、排斥反应以及微生物感染等不良反应中发挥重要功能。本文对NLRP3在器官移植不良反应发病机制中的作用及调控方式等最新研究进展进行综述。Organ transplantation will lead to some adverse events related to inflammation.NLRP3 inflammasome is an important molecule in the innate immune system that regulates inflammatory responses,NLRP3 plays a key role in adverse events such as ischemia-reperfusion injury,rejection,and microbial infection caused by liver,kidney and other organ transplants.Therefore,this article will review the latest research progress on the pathogenesis and signal pathways of NLRP3 regulation involved in transplantation.

关 键 词：NLRP3炎性小体 固有免疫 不良反应 移植 

分 类 号：R617[医药卫生—外科学]