热应激对鸡肠道屏障的影响及损伤机制研究进展  

Research Progress on Heat Stress on Intestinal Barrier Injury in Poultry

作　　者：周慧爽 李艳君 林树乾[2] 杨世发[2] 刘月月[2] 殷圣洁 何善平 孔芳 殷斌[2,3] 万仁忠 ZHOU Huishuang;LI Yanjun;LIN Shuqian;YANG Shifa;LIU Yueyue;YIN Shengjie;HE Shanping;KONG Fang;YIN Bin;WAN Renzhong(College of Animal Science and Technology,Shandong Agricultural University,Shandong Tai’an 271018,China;Poultry Research Institute,Shandong Academy of Agricultural Sciences,Shandong Ji’nan 250023,China;Delisi Industrial Park,Shandong Weifang 262216,China)

机构地区：[1]山东农业大学动物科技学院,山东泰安271018 [2]山东省农业科学院家禽研究所,山东济南250023 [3]得利斯集团有限公司,山东潍坊262216

出　　处：《中国畜牧杂志》2024年第2期71-77,共7页Chinese Journal of Animal Science

基　　金：山东省自然科学基金项目(ZR2020QC194);山东省科技型中小企业创新能力提升项目(2021TSGC1271、2021TS GC1275、2022TSGC1056)。

摘　　要：热应激通过上调皮质醇激素,升高血清内毒素含量,上调肠道内炎症、氧化、凋亡水平增加肠道通透性,最终引发机体系统性炎症反应综合征(SIRS)、多器官功能障碍(MODS),给养殖业造成损失。近年来全球温度持续上升,热应激造成的畜牧业损失引起广泛关注。本文总结了热应激影响鸡生产性能、肠道形态结构、肠道屏障功能(包括炎症反应、氧化应激、凋亡水平)的相关研究及机制,旨在为防治家禽高温应激提供理论参考。Heat stress(HS)leads to increased intestinal permeability by up-regulating the levels of cortisol hormone,intestinal oxidation,inflammation and apoptosis,and increase the content of serum endotoxin,eventually induce SIRS and MODS,which will cause losses to animal husbandry.In recent years,due to the continuous rise of global temperature,the loss of animal husbandry caused by heat stress has attracted widespread attention.In this paper,the related research and mechanism of HS affecting chicken performance,intestinal morphological structure and intestinal barrier function in recent years were summarized,including oxidative stress,inflammatory reaction and apoptosis level,which provided theoretical reference for the prevention and treatment of high temperature stress in poultry.

关 键 词：热应激 肠道屏障 家禽 紧密连接 

分 类 号：S831.1[农业科学—畜牧学]