邻苯二甲酸二(2-乙基己基)酯对睾丸的毒性作用及机制  

Toxicity and Mechanism of Di-(2-ethylhexyl)Phthalate on Testis

作　　者：冯安妮 孙任任 肖玉波 曾昭明 莫中成 谢远杰 FENG An-Ni;SUN Ren-Ren;XIAO Yu-Bo;ZENG Zhao-Ming;MO Zhong-Cheng;XIE Yuan-Jie(Department of Histology and Embryology,Institute of Basic Medical Sciences,Guilin Medical University,Guilin 541199,China;School of Public Health and Laboratory Medicine,Hunan University of Medicine,Huaihua 418000,China;Joint Laboratory of Chronic Disease Prevention and Research in Guilin Medical University&Hunan Mingshun Pharmaceutical Co.,Ltd,Shaodong 422800,China)

机构地区：[1]桂林医学院基础医学院组织学与胚胎学教研室,桂林541199 [2]湖南医药学院公共卫生与检验医学院,怀化418000 [3]桂林医学院-明舜制药慢性病防治研究联合实验室,邵东422800

出　　处：《生物化学与生物物理进展》2024年第3期555-563,共9页Progress In Biochemistry and Biophysics

基　　金：湖南明舜制药有限公司横向合作项目(2021GLHX03)资助。

摘　　要：邻苯二甲酸二(2-乙基己基)酯(DEHP)是目前使用最广泛的增塑剂之一,DEHP具有毒性,长期暴露会对机体的多个系统产生损害,特别是对雄性生殖系统的毒性作用更为明显。DEHP通过诱导氧化应激、调控细胞自噬,促进生精细胞和睾丸间质细胞凋亡、抑制睾酮合成、破坏血-睾屏障、诱导睾丸支持细胞铁死亡以及影响子代雄性的表观遗传等,造成生殖器官的病理损伤。本文就DEHP对睾丸的毒性作用及机制进行综述,拟为男性生殖障碍的防治研究提供新思路。Di-(2-ethylhexyl)phthalate(DEHP)is currently one of the most widely used plasticizers,widely found in all kinds of items,such as children’s toys and food packaging materials,but also added to wallpaper,cable protective agents and other building decoration materials.DEHP is toxic and absorbed by the human body through respiratory tract,digestive tract and skin contact,which can cause damage to multiple systems,especially the male reproductive system,and testis is an important target organ.Oxidative stress injury is the core mechanism of spermatogenesis disorder caused by DEHP.DEHP exposure can cause oxidative stress or reactive oxygen species(ROS)increase in germ cells,and on this basis,promote cell apoptosis or cause excessive autophagy.The toxicity of DEHP to Leydig cells is mainly to interfere with the synthesis of steroid hormones.For Sertoli cells,ferroptosis and destruction of the blood-testis barrier are common injury mechanisms.In addition,gene methylation caused by DEHP not only affects the spermatogenic process,but also has epigenetic effects on offspring.In this paper,we reviewed the pathological damage,germ cell toxicity and epigenetic effects of DEHP on testis,and focused on the damage and molecular mechanism on testicular spermatogenic cells,Leydig cells and Sertoli cells.Future research is required to elucidate the body’s clearance mechanism and treatment plan after exposure to DEHP and whether DEHP will damage the function of myoid cells.It is hoped that this can provide new ideas for prevention and treatment of male reproductive disorders resulting from long-term exposure to plastic products.

关 键 词：邻苯二甲酸二(2-乙基己基) 酯 睾丸 生殖毒性 氧化应激 铁死亡 

分 类 号：R697.22[医药卫生—泌尿科学]