生长分化因子5与代谢性疾病  

Growth Differentiation Factor 5 and Metabolic Diseases

作　　者：王天幕 任无竞 田振军[1] WANG Tian-Mu;REN Wu-Jing;TIAN Zhen-Jun(Institute of Sports and Exercise Biology,School of Physical Education,Shaanxi Normal University,Xi'an 710119,China)

机构地区：[1]陕西师范大学体育学院暨运动生物学研究所,西安710119

出　　处：《生物化学与生物物理进展》2024年第3期564-574,共11页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(32171128)资助项目。

摘　　要：生长分化因子5(growth/differentiation factor-5,GDF-5)属于转化生长因子β(transforming growth factor-β,TGF-β)家族,在骨、软骨、心脏、大脑、肾脏、骨骼肌和肌腱、肝脏以及脂肪等多个器官组织中表达。GDF-5与其受体BMPR-I/BMPR-II结合,激活Smad1/5/8、PI3K/Akt、p38-MAPK等信号,发挥促进细胞增殖分化、减少氧化应激损伤、细胞凋亡和组织纤维化等生物学功能。目前针对GDF-5的研究多聚焦在骨、软骨与肌腱的生长和修复等方面,而在其他器官中的生物学作用鲜有报道。因此,本文通过梳理和总结近年来GDF-5与代谢性疾病的研究进展,为GDF-5在改善代谢性疾病防治提供新的见解和理论依据。Growth/differentiation factor-5(GDF-5)belongs to transforming growth factor-β(TGF-β)family,which is expressed in bone,cartilage,heart,brain,kidney,skeletal muscle and tendon,liver,fat and other organs and tissues as well.GDF-5 binds to receptor BMPR-I/BMPR-II and activates different signaling pathways such as smad1/5/8,PI3K/Akt,p38-MAPK.For a long time,numerous studies have shown that GDF-5 plays an important role in protecting joints.However,researchers have found GDF-5 also plays significant biological functions in other organs.For example,GDF-5 improves cardiac function by reducing oxidative stress and fibrosis in infarcted hearts.GDF-5 can also reduce oxidative stress in the brain and increase the number of neurons in effort to delay the progression of Alzheimer’s disease and Parkinson’s disease.It is a situation,research on GDF-5,at present,mainly focuses on the growth and repair of bone,cartilage and tendons,while there are few reports on its biological effects in other organs.Therefore,this article reviews and summarizes the research progress on GDF-5 and metabolic diseases in recent years in order to provide new insights and theoretical basis for the role of GDF-5 in improving metabolic diseases.

关 键 词：代谢性疾病 生长分化因子5 BMP-14 炎症 氧化应激 

分 类 号：R589[医药卫生—内分泌]