Research progress of ICOSL/ICOS pathway in maternal-fetal immune tolerance  

作　　者：MEI Jiao-qi YANG Xiao-hui LIMENG Yong-wei MA Yan-lin HUANG Yuan-hua 

机构地区：[1]Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Reseach/Department of Reproductive/The First Affiliated Hospital of Hainan Medical University/Hainan Provincial Clinical Research Center for Thalassemia/Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University/Haikou Key Laboratory for Preservation of Human Genetic Resource,The First Affiliated Hospital of Hainan Medical University,Haikou 571199,China

出　　处：《Journal of Hainan Medical University》2023年第23期70-73,共4页海南医学院学报（英文版）

基　　金：National Natural Science Foundation of China(No.81960283,82072880)。

摘　　要：Co-signaling molecules are molecules whose ligands on the surface of cells interact with receptors on the surface of T cells to convey stimulatory or inhibitory signals to regulate immune responses.Co-signaling molecules play an important role in tumor and autoimmune diseases.Lately,studies have shown that co-signaling molecules are also involved in the regulation of maternal-fetal immune tolerance,and abnormalities of co-signaling molecules may lead to the imbalance of maternal-fetal immune tolerance,resulting in recurrent abortion,eclampsia and other pregnancy complications.ICOSL/ICOS is a ligand and receptor of costimulatory signals,which regulates maternal and fetal immune tolerance by participating in T cell differentiation and Th1 and Th2 cytokine secretion.Therefore,this article reviews the structure of ICOSL/ICOS,the distribution of ICOSL/ICOS at the maternal-fetal interface and its immune regulation during pregnancy,in order to provide new ideas for the future study of immunotherapy of pregnancy complications caused by abnormal co-signaling molecules.

关 键 词：Co-stimulatory molecules ICOSL/ICOS Immune tolerance TH1 TH2 

分 类 号：R714.25[医药卫生—妇产科学]