Inhibitory effect of water soluble propolis on oxidative damage in rats with ulcerative colitis  

作　　者：ZHOU Hua ZHANG Min JIANG Wen-tao 

机构地区：[1]Department of Physiology,Anhui Medical College,Hefei 230601,China

出　　处：《Journal of Hainan Medical University》2023年第18期15-22,共8页海南医学院学报（英文版）

基　　金：Wang Jianhua Research and Innovation Team of Anhui Medical College in 2022(No.WJH202009t);General Project of Natural Science Research in Universities of Anhui Province in 2022(No.ZR2022B007)。

摘　　要：Objective:To investigate the effects of water-soluble propolis(WSP)on the levels of colonic mucosal inflammation and oxidative stress in rats with ulcerative colitis(UC).Methods:The UC rat model was made by sodium dextran sulfate(DSS).Forty-eight male rats were randomly divided into six groups:the normal group(N group),the control group(C group),the positive control group(P group),the low-dose propolis group(L group),he medium-dose propolis(M group)and the high-dose propolis group(H group).The protective effect of WSP on DSS induced UC rats was evaluated by preadministration and re-construction model.Body mass,disease activity index(DAI),blood stool,colon length,intestinal mucosal damage index(CMDI)of rats were observed.The indexes of medulla peroxidase(MPO),superoxidase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)in colon tissue were determined by ELISA.Results:the oxidative stress level of colon tissue in the model group was increased and neutrophils were activated.After medium and high concentration propolis intervention,the oxidative stress level was reduced and the colonic inflammatory injury was relieved.Conclusion:WSP can improve the activity of SOD,GSH-Px and other endogenous antioxidant enzymes,reduce oxidative stress products,inhibit the activity of neutrophil and other mechanisms to relieve intestinal inflammation in experimental UC rat model.

关 键 词：Water-soluble propolis Ulcerative colitis Oxidative stress Intestinal mucosal barrier Natural products 

分 类 号：R285.5[医药卫生—中药学]