基于N-亚硝基导向的芳烃C(sp^(2))—H键官能团化研究进展  

Recent Advances in Functionalization of Aromatic C(sp^(2))—H Bonds Based on N-Nitroso Direction

作　　者：王芳[1] 王磊 Wang Fang;Wang Lei(School of Pharmaceutical and Chemical Engineering,Advanced Research Institute and College of Pharmaceutical Sciences,Taizhou University,Taizhou,Zhejiang 318000)

机构地区：[1]台州学院医药化工学院高等研究院和药学院,浙江台州318000

出　　处：《有机化学》2023年第12期4157-4167,共11页Chinese Journal of Organic Chemistry

基　　金：浙江省自然科学基金(No.LZ22B020003);国家自然科学基金(No.22071171)资助项目.

摘　　要：近年来,N-亚硝基通过与过渡金属螯合协同活化芳烃C(sp^(2))—H键,成功构建了C—C键和C—杂原子键的例子已有报道.它基于内部N—N键的氧化断裂,在反应过程中无需添加外部氧化剂,反应结束后可自行离去,发展成为一种新型高效的导向基团,受到了研究者的广泛关注.总结了基于N-亚硝基导向的芳烃C(sp^(2))—H键官能团化的最新研究进展.In recent years,examples of activation of aromatic C(sp^(2))—H bonds successfully constructing C—C bonds and C—heteroatom bonds through N-nitroso synergistic chelation with transition metals have been reported.It is based on the oxidative cleavage of internal N—N bonds,and does not require the addition of external oxidants during the reaction process.After the reaction completion,it can leave on its own,which has made it develop into a new and efficient directing group,and has received widespread attention from researchers.The latest research progress on functionalization of aromatic C(sp^(2))—H bonds based on N-nitroso direction is summarized.

关 键 词：C—H键活化 导向基团 N-亚硝基 芳烃官能化 

分 类 号：O621.251[理学—有机化学]