锡粉促进下1,3-二取代-1,3-二氢异苯并呋喃化合物的合成  

Tin Powder-Promoted Synthesis of 1,3-Disubstituted 1,3-Dihydroisobenzofuran Compounds

作　　者：唐朵朵 黄丹凤[1] 王克虎[1] 马虎 冯杨 任园园 王君姣 胡雨来[1] Tang Duoduo;Huang Danfeng;Wang Kehu;Ma Hu;Feng Yang;Ren Yuanyuan;Wang Junjiao;Hu Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2023年第12期4227-4238,共12页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21861033,22061037)资助项目.

摘　　要：探究了锡粉促进下邻甲酰基查尔酮与烯丙基溴的串联烯丙基化/oxa-Michael加成反应,为合成具有潜在生物活性的1,3-二取代-1,3-二氢异苯并呋喃提供了简便的方法.该方法具有反应时间短,操作简单,产率优良等优点,并进一步拓宽了锡粉促进下的反应类型.An efficient approach for the construction of 1,3-disubstituted-1,3-dihydroisobenzofuran compounds was developed through tin powder mediated tandem allylation/oxa-Michael addition reaction of o-formyl chalcones with various allyl bromides under mild reaction conditions.This method is easy to operate and can tolerate various functional groups to give the corresponding 1,3-disubstituted-1,3-dihydroisobenzofuran compounds in good to excellent yields.

关 键 词：锡粉 烯丙基溴 邻甲酰基查尔酮 1 3-二氢异苯并呋喃 

分 类 号：O626.11[理学—有机化学]