手性P,N,N-配体/钯催化的不对称烯丙基取代反应  

Chiral P,N,N-Ligands for Pd-Catalyzed Asymmetric Allylic Substitutions

作　　者：秦浩 侯传金 梁丁化 何心伟[2] 李玲 胡向平 Qin Hao;Hou Chuanjin;Liang Dinghua;He Xinwei;Li Ling;Hu Xiangping(School of Light Industry and Chemical Engineering,Dalian Polytechnic University,Dalian,Liaoning 116034;Key Laboratory of Functional Molecular Solids,Ministry of Education,Anhui Normal University,Wuhu,Anhui 241000;Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,Liaoning 116023)

机构地区：[1]大连工业大学轻工与化学工程学院,辽宁大连116034 [2]安徽师范大学功能分子固体教育部重点实验室,安徽芜湖241000 [3]中国科学院大连化学物理研究所,辽宁大连116023

出　　处：《有机化学》2024年第1期282-290,共9页Chinese Journal of Organic Chemistry

基　　金：辽宁省自然科学基金(No.2022-MS-345);功能分子固体教育部重点实验室(No.FMS201906)资助项目.

摘　　要：P,N,N-配体是近年来发展起来的在不对称催化反应中具有广泛应用的一类手性配体.将手性P,N,N-配体应用于钯催化不对称烯丙基取代反应研究.结果表明,在较温和条件下,含C、N和O的各类亲核试剂均能顺利发生反应,获得良好的产率和对映选择性(产率高达97%,93%ee).Chiral P,N,N-ligands are a new type of ligands developed in recent years,which have been widely used in asymmetric catalytic reactions.In this study,chiral P,N,N-ligands were applied to palladium-catalyzed asymmetric allylic substitution reactions.The results showed that under mild conditions,various nucleophiles containing carbon,nitrogen and oxygen could react smoothly,achieving good yields(up to 97%yield)and enantioselectivities(up to 93%ee).

关 键 词：P N N-配体 不对称烯丙基取代 钯 

分 类 号：O621.251[理学—有机化学]