H_(1)抗组胺药联合治疗过敏性鼻炎的疗效和安全性(英文)  

Efficacy and safety of H_(1) antihistamines combination therapy for allergic rhinitis

作　　者：沈开丽 罗敏 董玄 张文志 唐富山 Shen Kaili;Luo Min;Dong Xuan;Zhang Wenzhi;Tang Fushan(Clinical Pharmacy Teaching and Research Office,School of Pharmacy,Zunyi Medical University,Zunyi Guizhou 563006,China;Department of Pharmacy,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563003,China)

机构地区：[1]遵义医科大学药学院临床药学教研室,贵州遵义563006 [2]遵义医科大学附属医院药剂科,贵州遵义563003

出　　处：《遵义医科大学学报》2024年第3期279-291,共13页Journal of Zunyi Medical University

基　　金：贵州省中药民族药2011协同创新中心[NO:黔教技(2022)26]。

摘　　要：目的 总结H_(1)抗组胺药物(AHs)联合治疗过敏性鼻炎(AR)的常见治疗方案,并分析其有效性和安全性。方法 我们对国内外8个数据库进行了全面检索,检索时间截止为2023年5月,研究方法遵循Arksey和O’Malley提出的方法论框架,并对纳入研究的质量进行了严格评估。结果 从初筛出的8 207篇相关文献中最终纳入70篇文献,共涵盖8种联合治疗方案。67篇文献报告称,2种AHs联合治疗比单一用药更有效;3篇文献表明,2种AHs联合治疗比3种AHs联合治疗或单一用药更加有效和安全。33篇文献得出结论,2种AHs联合治疗比单一AHs治疗具有更好的安全性。此外,1篇文献发现,3种AHs联合治疗比单一治疗更有效,但它与更高的药物不良反应(ADR)发生率有关。结论 根据目前的研究证据,与单一治疗或3种AHs联合治疗AR相比,2种AHs的联合治疗已显示出优越的疗效和安全性。氮卓斯汀鼻喷剂联合地氯雷他定片是治疗AR最常见的治疗方案。Objective To perform a scoping review to analyze the common treatment regimens of H_(1) antihistamines(AHs)combination therapy for allergic rhinitis(AR)and evaluate their efficacy and safety.Methods We conducted a comprehensive search of 8 databases from both China and abroad in May 2023,following the methodological framework proposed by Arksey and O’Malley.The quality of the included studies was rigorously evaluated.Results A total of 70 studies,covering 8 combination therapy regimens were included from 8207 related literatures.Sixty-seven studies reported that 2 AHs combination therapy was more effective than monotherapy,and 3 studies indicated that 2 AHs combination therapy was more effective and safer than 3 AHs combination therapy or monotherapy.Thirty-three studies concluded that 2 AHs combination therapy had a better safety profile than single AHs therapy.Additionally,1 study found that 3 AHs combination therapy was more effective than monotherapy,but it was associated with a higher incidence of adverse drug reactions(ADRs).Conclusion Based on the current evidence,2 AHs combination therapy has demonstrated superior efficacy and safety compared to monotherapy or 3 AHs combination therapy for AR.Specifically,the combination of Azelastine nasal spray and Desloratadine tablets has emerged as the most commonly utilized treatment regimen in the review.

关 键 词：过敏性鼻炎 药物不良反应 联合治疗 疗效 H_(1)抗组胺药 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]