甲状腺功能减退与肾功能改变因果关系的两样本孟德尔随机化研究  

Two-Sample Mendelian Randomization Analysis of the Causal Relationship between Hypothyroidism and Renal Function

作　　者：李轩维 李文来 李玥 马聪媛 朱平[1] Li Xuanwei;Li Wenlai;Li Yue;Ma Congyuan;Zhu Ping(Department of Nephrology,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Department of Endocrinology,Affiliated Renhe Hospital of China Three Gorges University,The Second College of Clinical Medical Science of China Three Gorges University,Yichang 443001,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]肾内科,湖北宜昌443003 [2]三峡大学第二临床医学院[三峡大学附属仁和医院]内分泌科,湖北宜昌443001

出　　处：《巴楚医学》2024年第1期72-77,共6页Bachu Medical Journal

基　　金：湖北省教育厅自然科学研究计划项目(No:B2017024);宜昌市医疗卫生研究项目(No:A20-2-002)。

摘　　要：目的:探讨甲状腺功能减退与肾功能改变的因果关联。方法:使用两样本孟德尔随机化(MR)分析方法,将甲状腺功能减退显著相关的单核苷酸多态性(SNPs)作为工具变量,进行甲状腺功能减退与肾功能因果关联的探讨。数据来源全基因组关联研究的汇总数据。结果:共29个SNPs纳入为工具变量。甲状腺功能减退与肾小球滤过率之间无明显因果关联:逆方差加权(OR=2.33,95%CI:0.03,7.88)、MR-Egger回归(OR=0.11,95%CI:0.03,3.11)、加权中位数(OR=0.62,95%CI:0.06,7.91)、简单模式(OR=1.55,95%CI:0.12,15.3)及加权模式(OR=0.77,95%CI:0.11,9.03)(均P>0.05)。留一法敏感性分析和Cochrane’s Q检验提示所得结果稳健且不存在异质性(P>0.05)。结论:甲状腺功能减退与肾功能改变不存在因果关联。Objective:To investigate the causal relationship between hypothyroidism and renal function.Methods:Two-sample Mendelian randomization(MR)analysis was used to investigate the causal association between hypothyroidism and renal function,with single nucleotide polymorphisms(SNPs)significantly associated with hypothyroidism as instrumental variables.Data were collected from genome-wide association studies.Results:A total of 29 SNPs were included as instrumental variables.There is no significant causal correlation between hypothyroidism and estimated glomerular filtration rate:inverse variance weighted(OR=2.33,95%CI:0.03,7.88),MR-Egger regression(OR=0.11,95%CI:0.03,3.11),weighted median estimator(OR=0.62,95%CI:0.06,7.91),simple model(OR=1.55,95%CI:0.12,15.3),and the weighted model(OR=0.77,95%CI:0.11,9.03).Additionally,leave-one-out sensitivity analysis and Cochrane's Q test suggested robust results with no heterogeneity(P>0.05).Conclusion:There is no causal correlation between hypothyroidism and renal function.

关 键 词：甲状腺功能减退 肾功能 孟德尔随机化 因果关联 

分 类 号：R581[医药卫生—内分泌]