运动病动物模型研究新进展  

Research Advances of Experimental Animal Models of Motion Sickness

作　　者：张卓儒 张敏[2,3] 李聪聪 刘玉辉 姜一弘 畅通 朱靖 黄立桂 周小燕[1] 王小成[2,3] ZHANG Zhuoru;ZHANG Min;LI Congcong;LIU Yuhui;JIANG Yihong;CHANG Tong;ZHU Jing;HUANG Ligui;ZHOU Xiaoyan;WANG Xiaocheng(Department of Pathology and Pathophysiology,Medical College of Yan’an University,Yan’an 716000,China;Center of Clinical Aerospace Medicine,School of Aerospace Medicine,PLA Air Force Medical University,Xi’an 710032,China;Department of Aviation Medicine,the First Affiliated Hospital,PLA Air Force Medical University,Xi’an 710032,China;Department of Otolaryngology-Head and Neck Surgery,the 908th Hospital,PLA Joint Logistics Support Force,Nanchang 360104,China)

机构地区：[1]延安大学医学院病理与病理生理学科组,延安716000 [2]中国人民解放军空军军医大学航空航天医学系航空航天临床医学中心,西安710032 [3]中国人民解放军空军军医大学第一附属医院空勤科,西安710032 [4]中国人民解放军联勤保障部队第908医院耳鼻咽喉头颈外科,南昌360104

出　　处：《实验动物科学》2024年第1期94-98,共5页Laboratory Animal Science

基　　金：军队保健专项科研课题(17BJZ24)。

摘　　要：随着运动病研究的不断深入,运动病模型的动物种类不断增多,判断标准和指标逐渐采用客观的行为学指标和生理学指标结合的方法。本文就近年来常用的运动病动物模型,从动物种类、造模方法和模型标准与判断指标,分析总结其方法和特点,整理收集运动病动物模型的评价方法,为运动病发病机制的探索、疾病严重程度客观评价、抗运动病药物研发及前庭稳定性训练方案制定等研究提供可靠的实验动物建模方法和观察指标。With the deepening of the research on motion sickness,the types of animal models of motion sickness are increasing,and the method of combining objective indicator of behavior and physiological indexes are gradually adopted as the criteria and indicators.This paper analyzes and summarizes the method and characteristics of animal models of motion sickness commonly used in recent years from the animal types,modeling method,model standards and indicators,and collects the evaluation method of animal models of motion sickness.To provide a reliable experimental animal modeling method and observation index for the exploration of pathogenesis of motion sickness,the objective evaluation of disease severity,the development of anti-motion sickness drugs and the development of vestibular stability training program.

关 键 词：运动病 动物模型 建模方法 评价方法 

分 类 号：Q95-3[生物学—动物学]