SNP分型检测技术及其在大鼠遗传检测中的应用  

SNP Genotyping Technologies and its Application in Genetic Monitoring in Rats

作　　者：李欢 岳秉飞[1] LI Huan;YUE Bingfei(National Rodent Laboratory Animal Resources Center,Institute for Laboratory Animal Resources,National Institutes for Food and Drug Control(NIFDC),Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院实验动物资源研究所、国家啮齿类实验动物资源库,北京102629

出　　处：《实验动物科学》2024年第1期104-107,共4页Laboratory Animal Science

基　　金：国家重点研发计划(2021YFF0703200)。

摘　　要：单核苷酸多态性(SNP)是第三代分子遗传标记,由于其广泛性、遗传稳定性、二态性及易于自动化分型的特点,成为当前实验动物遗传检测领域中重要研究的遗传标记。本文概述了SNP概念及特点,重点阐述不同种类SNP分型技术,并对该技术在大鼠遗传检测研究中的应用进行回顾和展望。Single nucleotide polymorphism(SNP)is the third generation of molecular genetic markers.Due to its universality,genetic stability,dimorphism and easy automatic typing,SNP has become an important genetic marker in the field of experimental animal genetic detection.Therefore,this paper briefly summarizes the characteristics and types of SNP,and focuses on several SNP typing techniques and the application of SNP in genetic detection in rats.

关 键 词：大鼠 单核苷酸多态性(SNP) SNP基因分型 遗传质量检测 

分 类 号：Q95-3[生物学—动物学]