胎儿先天畸形超声监测结果分析  

Analysis of the fetal congenital malformation monitoring results in Liaocheng second people's hospital from 2020 to 2023

作　　者：张静[1] 江明[1] 张燕 岳家伊 滕玲玲[1] ZHANG Jing;JIANG Ming;ZHANG Yan;YUE Jiayin;TENG Lingling(Liaocheng Second People's Hospital,Shandong Province,252600;Liaocheng People's Hospital of Shandong Province)

机构地区：[1]山东省聊城市第二人民医院,252600 [2]山东省聊城市人民医院

出　　处：《中国计划生育学杂志》2024年第3期512-516,共5页Chinese Journal of Family Planning

基　　金：聊城市科技局项目(2023032085)。

摘　　要：目的:分析2020-2023年聊城市第二人民医院胎儿先天畸形(CM)监测结果并分析影响因素。方法:收集2020年1月-2023年12月在本院产前检查的孕妇5852例,根据超声筛查结果并分成畸形组和无畸形组。对孕妇相关资料行单因素分析,并通过多因素分析确定胎儿CM的影响因素。结果:5852例孕妇中胎儿存在CM有56例,CM发生率为0.96%;在畸形部位上,以心血管系统为主(30.4%),其次为神经系统畸形(23.2%);畸形组和无畸形组在妊娠年龄≥35岁、异常妊娠史、孕期毒物接触史、孕期用药史、孕期感染病原体、孕期补充叶酸、孕期患糖尿病或高血压、配偶吸烟间存在差异(P<0.05);logistic回归分析显示,胎儿CM的危险因素主要为妊娠年龄≥35岁(OR=2.289)、孕期有毒物接触史(OR=3.152)、孕期有用药史(OR=2.516)、孕期感染病原体(OR=2.449)、孕期患糖尿病或高血压(OR=2.792)、配偶吸烟(OR=2.584),保护因素为孕期补充叶酸(OR=0.478)。结论:本次调查妊娠年龄≥35岁、孕期有毒物接触史、孕期有用药史、孕期感染病原体、孕期患糖尿病或高血压、配偶吸烟与胎儿CM发生有关,补充叶酸可减少胎儿CM发生。提示对上述高危因素予以精准干预,并指导孕妇有效补充叶酸,以降低胎儿CM发生风险。Objective:To analyze the monitoring results of the fetal congenital malformations(CM)in Liaocheng second people's hospital from 2020 to 2023,and to study the influencing factors of the fetal CM.Methods:A total of 5852 pregnant women who underwent prenatal examinations in hospital from January 2020 to December 2023 were collected.These women were divided into group A(women with the suspective fetal malformation)and group B(women without the fetal malformation)based on their ultrasound screening results.The relevant information of the pregnant women was analyzed by single factor analysis,and the influencing factors of the fetal CM were analyzed by multiple factor analysis.Results:Among 5852 pregnant women,there were 56 cases with fetal CM,with the incidence of the fetal CM rate of 0.96%.The site of malformation of the fetuses was mainly in cardiovascular system(30.4%),and followed by the neurological malformations(23.2%).There were significant differences in the age of pregnancy≥35 years old,the history of abnormal pregnancy,the history of toxic exposure during pregnancy,the history of medication during pregnancy,the pathogen infection during pregnancy,the folic acid supplementation during pregnancy,the diabetes or hypertension occurrence during pregnancy,and the smoking of the spouse of the women between group A and group B(P<0.05).Logistic regression analysis showed that the main risk factors of the fetal CM of the women were their age of pregnancy≥35 years old(OR=2.289),their history of toxic exposure during pregnancy(OR=3.152),their history of medication during pregnancy(OR=2.516),their pathogen infection during pregnancy(OR=2.449),their diabetes or hypertension occurrence during pregnancy(OR=2.792)and the smoking of their spouse(OR=2.584).The folic acid supplementation during pregnancy was a protective factor of the fetal CM of the women(OR=0.478).Conclusion:The age of pregnancy≥35years old,the history of exposure to toxic substances during pregnancy,the history of medication during pregnancy,the infecti

关 键 词：胎儿先天畸形 超声监测 影响因素 

分 类 号：R714.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]