基于Cite Space文献分析并观察不同剂量艾司氯胺酮在无痛人工流产术应用效果  

Application effect of the different dosages of esketamine used in painless induced abortion based on Cite Space literature analysis

作　　者：薛孟 任应斌[2] 田瑞丽 XUE Meng;REN Yingbin;TIAN Ruili(Changzhi Medical College,Changzhi,Shanxi Province,046000;Changzhi Maternal and Child Health Care Hospital,Shanxi Province)

机构地区：[1]长治医学院,046000 [2]山西省长治市妇幼保健院

出　　处：《中国计划生育学杂志》2024年第3期527-532,共6页Chinese Journal of Family Planning

基　　金：山西省医师协会临床科研项目(YSXH-RF2022MZ007)。

摘　　要：目的:运用Cite Space对中国知网(CNKI)数据库主题词“无痛人工流产”和“艾司氯胺酮”的文献进行分析,寻找无痛人工流产研究热点,探讨不同剂量艾司氯胺酮在无痛人工流产术中应用效果。方法:分别以“无痛人工流产”“艾司氯胺酮”为主题词,检索CNKI数据库,将检索得到文献导入CiteSpace软件,荟聚分析2012年1月-2023年1月国内外无痛人工流产研究的前沿热点。选取2023年3-6月本院门诊行无痛人工流产者160例,采用队列分组,艾司氯胺酮(0.1mg/kg)+丙泊酚(E1组),艾司氯胺酮(0.2mg/kg)+丙泊酚(E2组),艾司氯胺酮(0.3mg/kg)+丙泊酚(E3组),芬太尼(1ug/kg)+丙泊酚(F组)。观察各组诱导前(T1)、宫口扩张时(T2)及手术结束(T3)时的心率(HR)、血压(BP)、血氧饱和度(SPO_(2))。记录受术者术后苏醒时间、丙泊酚用量、苏醒后15minVAS评分、麻醉效果以及不良反应发生率。结果:纳入分析的中文文献2210篇,热点变迁分析显示艾司氯胺酮关临床研究文献增多,为无痛人工流产研究热点。临床观察显示,E1组、E2组、E3组T2、T3时MAP和SPO_(2)均高于F组,T2时HR均高于F组(均P<0.05),T3时各组HR无差异(P>0.05)。E2和E3组VAS评分均低于E1组和F组,E1、E2、F组苏醒时间和嗜睡发生率均优于E3组,E1组、E2组、E3组麻醉效果优良率(95.0%、97.5%、97.5%)均优于F组(80.0%),呼吸抑制发生率(5.0%、7.5%、5.0%)均低于F组(27.5%)(均P<0.05)。各组头晕头痛、恶心呕吐、注射痛发生率无差异(P>0.05)。结论:基于CNKI数据库文献荟萃分析发现艾司氯胺酮是目前无痛人工流产领域研究热点,本文临床观察0.2mg/kg艾司氯胺酮复合丙泊酚用于无痛人工流产效果及安全性最佳。Objective:To analyze the literature with the subject words of"painless abortion"and"esketamine"in domestic CNKI by Cite Space,to find the research hotspots on the painless abortion,and to explore the application effect of the different dosages of esketamine used in painless induced abortion.Methods:The literatures were searched by the subject words of"painless abortion"and"Esketamine"in the database of China National Knowledge Network(CNKI),and the retrieved literatures were imported into Cite Space software.The forefront and hot spots of the painless abortion research at home and abroad from January 2012 to January 2023 were analyzed by Meta-analysis.160 women who wanted painless abortion in the outpatient department from March to June 2023were selected in a cohort study,which included the women with esketamine(0.1mg/kg)combined with propofol for painless abortion in group E1,the women with esketamine(0.2mg/kg)combined with propofol for painless abortion in group E2,the women with esketamine(0.3mg/kg)combined with propofol for painless abortion in group E3 and the women with fentanyl(1ug/kg)combined with propofol in group F.The values of heart rate(HR),blood pressure(BP)and oxyhemoglobin saturation(SPO_2)of the women in the four groups before anesthetic induction(T1),during dilation of uterine orifice(T2)and after abortion(T3)were observed.The time of recovery,the dosage of propofol,the score of VAS at 15min after recovery,the anesthetic effect and the incidence of adverse reactions of the women in the four groups were recorded.Results:A total of 2210Chinese articles were included for meta-analysis.The analysis of hotspots showed that the clinical research literature on esketamine used in the painless abortion had increased,and which was a research hotspot of the painless abortion.The clinical observation showed that the values of MAP and SPO2of the women in group E1,group E2and group E3at T2and T3were significantly higher than those of the women in group F,and the HR value of the women in group E1,group E2and g

关 键 词：无痛人工流产 艾司氯胺酮 芬太尼 丙泊酚 文献荟萃 研究热点 临床观察 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]