New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves  

作　　者：SUN Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI Hui-Liang WANG Jinxin 

机构地区：[1]School of Pharmacy,Second Military Medical University,Shanghai 200433,China [2]State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 201203,China

出　　处：《Chinese Journal of Natural Medicines》2024年第2期161-170,共10页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82141203,82003624,82004003,82004215);the Science and Technology Commission of Shanghai Municipality(Nos.20YF1458700,20YF1459000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004);Shanghai Frontiers Science Center of TCM Chemical Biology,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.16DZ2280200).

摘　　要：Our continued works on the chemical constituents of Ginkgo biloba(G.biloba)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from G.biloba.The chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR experiments.Furthermore,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关 键 词：Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside 

分 类 号：R284.1[医药卫生—中药学]