滑液组分对“软-软”配副关节材料摩擦学行为的影响  

The influence of synovial fluid components on the tribological behavior of"soft-soft"joint pair materials

作　　者：岑佳佳 张德坤[1] 陈琴 张欣悦[1] 冯存傲 冯海燕 陈凯[1] CEN Jiajia;ZHANG Dekun;CHEN Qin;ZHANG Xinyue;FENG Cunao;FENG Haiyan;CHEN Kai(School of Materials and Physics,China University of Mining and Technology,Xuzhou 221116,China;School of Chemical Engineering,China University of Mining and Technology,Xuzhou 221116,China)

机构地区：[1]中国矿业大学材料与物理学院,徐州221116 [2]中国矿业大学化工学院,徐州221116

出　　处：《清华大学学报（自然科学版）》2024年第3期454-470,共17页Journal of Tsinghua University(Science and Technology)

基　　金：清华大学高端装备界面科学与技术全国重点实验室开放基金项目(SKLTKF21B15);中国科学院兰州化学物理研究所固体润滑国家重点实验室开放基金项目(LSL-2107)。

摘　　要：人体内关节滑液中各成分浓度的变化对人工关节滑动配副的摩擦学行为具有重要影响。该文基于人工关节置换后关节滑液的各组分浓度,以聚醚醚酮(polyether-ether-ketone,PEEK)和高交联聚乙烯(highly crosslinked polyethylene,XLPE)组成的“软-软”关节配副为研究对象,体外配制不同浓度的白蛋白(albumin,Alb)、γ-球蛋白(γ-globulin,γ-Glo)、透明质酸(hyaluronic acid,HA)和脂质体(phospholipids,PLs)等人体关节滑液主要成分的复合滑液,研究了不同成分复合滑液润滑条件下PEEK-XLPE关节配副的摩擦磨损行为,探明了滑液组分和浓度对“软-软”关节配副摩擦磨损的影响机制,揭示了“软-软”关节配副在不同成分复合滑液润滑作用下的磨损机理。结果表明:复合滑液中的4种主要成分均对“软-软”配副人工关节材料的摩擦磨损性能有较大影响,其中γ-Glo浓度对摩擦系数(coefficient of friction,COF)影响较大,当γ-Glo浓度由5.83mg/mL增加至8.75mg/mL时,摩擦系数增加了29.4%;总蛋白质浓度对磨损率影响较大,由15mg/mL Alb+3.75mg/mL γ-Glo增加至35mg/mL Alb+8.75mg/mL γ-Glo时,磨损率增加了166.0%。当复合滑液中γ-Glo或总蛋白质浓度过高时,蛋白质在摩擦表面发生不良黏附,使“软-软”配副关节材料的磨损加剧。此外,蛋白质混合液中同时加入HA和PLs,能促进Alb吸附而抑制γ-Glo吸附。[Objective] The artificial joint is lubricated using synovial fluid,and variations in the synovial fluid components considerably affect the tribological behavior of the sliding pair of the artificial joint.[Methods]Herein,the"soft-soft"joint pair materials composed of polyether-ether-ketone(PEEK)and highly crosslinked polyethylene(XLPE)are studied based on the composite synovial fluid content following artificial joint replacement.The friction and wear behaviors of the PEEK-XLPE"soft-soft"joint pair materials lubricated via different composite synovial fluids,including albumin(Alb),-globulin(y-Glo),hyaluronic acid(HA),and phospholipids(PLs),are studied.The mechanisms behind the effect of the composite synovial fluid composition and content on the friction and wear of"soft-soft"joint pair materials and wear mechanism of"soft-soft"joint pair materials under different composite synovial fluid are elucidated.[Results]The results showed that the four primary components of the composite synovial fluid had a substantial influence on the friction and wear properties of the artificial joint materials,with the-Glo content markedly affecting the friction coefficient.When the-Glo content increased from 5.83 mg/mL to 8.75 mg/mL and total protein content increased from 15 mg/mL Alb+3.75 mg/mL-Glo to 35 mg/mL Alb+8.75-Glo,the friction coefficient increased by 29.4%and 28.7%,while the wear rate increased by 24.6%and 166.0%,respectively.Moreover,excessively high-Glo or total protein content in the composite synovial fluid caused poor protein adhesion between friction surfaces.The wear of"soft-soft"joint pair materials was aggravated when"soft-soft"joint pair materials were used.The changes in the PLs and HA contents of the composite synovial fluid had little influence on the tribological properties of these"soft-soft"joint pair materials,but their effects on wear properties were significant.When the PLs content increased from 0.15 mg/mL to O.45 mg/mL,the friction coefficient changed little,but the wear rate decreased by 29.5%.Add

关 键 词：复合滑液 蛋白质 透明质酸 脂质体 摩擦磨损 

分 类 号：R318[医药卫生—生物医学工程]