First detection of cutavirus DNA in stools of patients with rheumatic diseases in Guangzhou,China  

作　　者：Yongzhi Li Liting Zheng Huan He Husheng Xiong Jiaqi Chen Hengbiao Sun Caiyun Chen Qiushuang Li Jiaqi Fu Fei Wu Yuhan Gao Juxian Xian Minyi Liang Gang Xiao Qing Chen 

机构地区：[1]Guangdong Provincial Key Laboratory of Tropical Disease Research,Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou,510515,China [2]Clinical Laboratory of Third Affiliated Hospital of Southern Medical University,Guangzhou,510500,China

出　　处：《Virologica Sinica》2023年第6期860-867,共8页中国病毒学（英文版）

基　　金：the National Natural Science Foundation of China(Grant No.81973107).

摘　　要：Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P=0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype.

关 键 词：Cutavirus(CuV) Rheumatic diseases PREVALENCE Risk factor Genetic characterization 

分 类 号：R511.9[医药卫生—内科学]