Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis  

作　　者：Weijie Wang Jinxuan Yang Pinfang Kang Jinsong Bai Xiaoli Feng Liuqi Huang Yiming Zhang Yuechun Wu Bi Tang Hongju Wang JianJie Jiang Minghua Li Bing Zhao Xinglou Yang 

机构地区：[1]Department of Cardiovascular Disease,The First Affiliated Hospital of Bengbu Medical College,Bengbu,233004,China [2]Yunnan Key Laboratory of Biodiversity Information,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,650201,China [3]State Key Laboratory of Genetic Engineering,School of Life Sciences,Zhongshan Hospital,Fudan University,Shanghai,200438,China [4]Kunming Third People's Hospital,Kunming,650041,China [5]Kunming National High-level Biosafety Research Center for Non-human Primates,Kunming Institute of Zoology,Chinese Academic of Sciences,Kunming,650107,China [6]Institute of Organoid Technology,Kunming Medical University,Kunming,650500,China

出　　处：《Virologica Sinica》2023年第6期971-974,共4页中国病毒学（英文版）

摘　　要：Dear editor,The pandemic of coronavirus disease-19(COVID-19)has lasted for more than three years,causing lots of extra death and posing a serious threat to public health.This pandemic swept the last global safety island in a matter of months,coinciding with the switch of zero-COVID policy of China.The causative agent,SARS-CoV-2,spreads globally and then lurks in the population with sporadic outbreaks in local areas.Meanwhile,the sequelae of convalescent COVID-19 patients receded slowly.The pantissue tropism of SARS-CoV-2 results in a wide range of symptoms in patients,including cardiovascular disorders.Cardiac complications occur in 20%–44%of hospitalized patients,which is an independent risk factor for COVID-19 mortality(Ma et al.,2022;Patone et al.,2022).Survivors of acute COVID-19 also have a substantial risk of cardiovascular disease burden lasting up to one year(Xie et al.,2022).

关 键 词：CARDIOVASCULAR MORTALITY acute 

分 类 号：R563[医药卫生—呼吸系统]