Bright,photostable and long-circulating NIR-II nanoparticles for whole-process monitoring and evaluation of renal transplantation  

作　　者：Rongyuan Zhang Ping Shen Yu Xiong Tianjing Wu Gang Wang Yucheng Wang Liping Zhang Han Yang Wei He Jian Du Xuedong Wei Siwei Zhang Zijie Qiu Weijie Zhang Zheng Zhao Ben Zhong Tang 

机构地区：[1]Clinical Translational Research Center of Aggregation-Induced Emission,The Second Affiliated Hospital,School of Medicine,School of Science and Engineering,Shenzhen Institute of Aggregate Science and Technology,The Chinese University of Hong Kong,Shenzhen(CUHK-Shenzhen),Shenzhen 518172,China [2]Center for AIE Research,Shenzhen Key Laboratory of Polymer Science and Technology,Guangdong Research Center for Interfacial Engineering of Functional Materials,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518061,China [3]School of Chemistry,Xiangtan University,Xiangtan 411105,China [4]HKUST-Shenzhen Research Institute,Shenzhen 518057,China [5]Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,The Hong Kong University of Science and Technology,Hong Kong,China [6]Department of Urology,The First Affiliated Hospital of Soochow University,Suzhou 215006,China [7]AIE Institute,Guangzhou 510530,China

出　　处：《National Science Review》2024年第2期202-215,共14页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(52003228,52273197,21788102);the National Key Research and Development Program of China(2023YFB3810001);the Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001,JCYJ20220818103007014,JCYJ2021324134613038,KQTD20210811090142053,JSGG20220606141800001,GJHZ20210705141810031);the Innovation and Technology Commission(ITC-CNERC14SC01).

摘　　要：Kidney transplantation is the gold standard for the treatment of end-stage renal diseases(ESRDs).However,the scarcity of donor kidneys has caused more and more ESRD patients to be stuck on the waiting list for transplant surgery.Improving the survival rate for renal grafts is an alternative solution to the shortage of donor kidneys.Therefore,real-time monitoring of the surgical process is crucial to the success of kidney transplantation,but efficient methods and techniques are lacking.Herein,a fluorescence technology based on bright,photostable and long-circulating aggregation-induced emission(AIE)active NIR-II nano-contrast agent DIPT-ICF nanoparticles for the whole-process monitoring and evaluation of renal transplantation has been reported.In the aggregated state,DIPT-ICF exhibits superior photophysical properties compared with the commercial dyes IR-26 and IR-1061.Besides,the long-circulating characteristic of the AIE nano-contrast agent helps to achieve renal angiography in kidney retrieval surgery,donor kidney quality evaluation,diagnosing vascular and ureteral complications,and assessment of renal graft reperfusion beyond renovascular reconstruction,which considerably outperforms the clinically approved indocyanine green(ICG).

关 键 词：aggregation-induced emission NIR-II imaging kidney transplantation nano-contrast agent ANGIOGRAPHY 

分 类 号：TQ421.7[化学工程] R699.2[医药卫生—泌尿科学]