重症心力衰竭急救中应用富马酸比索洛尔片联合地高辛片的疗效分析  

Analysis of the Clinical Efficacy of Bisoprolol Fumarate Tablets Combined with Digoxin Tablets in Emergency Aid of Severe Heart Failure

作　　者：黄军 Huang Jun(Guigang People's Hospital,Guigang 537100,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]贵港市人民医院,广西壮族自治区贵港537100

出　　处：《中外医药研究》2024年第1期42-44,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察心力衰竭重症患者急救治疗中应用富马酸比索洛尔片联合地高辛片的效果。方法:选取2020年1月—2022年1月贵港市人民医院收治的重症心力衰竭患者84例为研究对象,按区间随机法分为参照组与干预组,各42例。参照组采用富马酸比索洛尔片治疗,干预组采用富马酸比索洛尔片联合地高辛片治疗。比较两组心功能指标、炎性因子水平、治疗效果及不良反应发生情况。结果:治疗前,两组心脏指数(CI)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、血清N末端B型脑钠肽(NT-proBNP)水平比较,差异无统计学意义(P>0.05);治疗后,两组CI、LVEDD、LVESD、LVEF、NT-proBNP水平均优于治疗前,干预组优于参照组,差异有统计学意义(P<0.05)。治疗前,两组高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后,两组hs-CRP、TNF-α、IL-6水平均降低,干预组低于参照组,差异有统计学意义(P<0.05)。干预组治疗效果有效率高于参照组,差异有统计学意义(P=0.043)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重症心力衰竭患者采用富马酸比索洛尔片联合地高辛片治疗效果显著,能够改善心功能与炎性因子水平,提高治疗效果,保障治疗安全性。Objective:To observe the clinical effectiveness of bisoprolol fumarate tablets combined with digoxin tablets in the emergency aid of severe heart failure.Methods:84 patients with severe heart failure admitted to Guigang People's Hospital from January 2020 to January 2022 were selected as the study subjects,and were divided into the reference group and the intervention group according to the interval randomization method,each with 42 cases.The reference group was treated with bisoprolol fumarate tablets,and the intervention group was treated with bisoprolol fumarate tablets combined with digoxin tablets.The cardiac function indexes,inflammatory factor levels,therapeutic effects and the occurrence of adverse reactions were compared between the two groups.Results:Before treatment,the following parameters of the two groups were compared with each other:the cardiac index(CI),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),and serum N-terminal B-type brain natriuretic peptide(NT-proBNP)levels,and the difference was not statistically significant(P>0.05);after the treatment,the parameters such like CI,LVEDD,LVESD,LVEF,and NT-proBNP levels of both groups were better than before treatment,and the intervention group was better than the reference group,and the difference was statistically significant(P<0.05).Before treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were compared between the two groups,and the difference was not statistically significant(P>0.05);after treatment,the levels of hs-CRP,TNF-α,and IL-6 were reduced in the two groups,and the intervention group was lower than that of the reference group,and the difference was statistically significant(P<0.05).The effective rate of therapeutic effect in the intervention group was higher than that in the reference group,and the difference was statistically significant(P=0.043).Comparison of the incidence of adve

关 键 词：心力衰竭 急救治疗 地高辛 比索洛尔 

分 类 号：R541.6[医药卫生—心血管疾病]